Pathology of Genetically Engineered and Other Mutant Mice. Группа авторов

      

      Table of Contents

      1  Cover

      2  Title Page

      3  Copyright Page

      4  List of Contributors

      5  Preface and Acknowledgments

      6  1 Introduction to Mouse Pathology The Use of Mice in Medical Research Understanding Diseases Found in Mutant Animals Mouse Pathology – Nomenclature Mouse Genetic Nomenclature Tumor Pathology Immunohistochemistry (IHC), Scoring, Image Analysis, and Other Supportive Research Pathology Techniques Publication of Erroneous Pathology Data: Inadvertent Fraud? Overall Organization of the Book Acknowledgments References

      7  2 The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research Introduction FAIR Data Access and Databases of Databases General Information on Inbred Laboratory Mice Large Scale Mutagenesis Background Strain Comparison Studies Mouse Pathology Image (Histopathology) Resources Organ/Disease Specific Resources Finding Mouse Models Use of Mouse Pathology Resources on Line; Citations, and Licenses Acknowledgments References

      8  3 Mouse Genetic Nomenclature Introduction Why Use Standardized Nomenclature? Inbred Mice Hybrid Mice (F1 and F2) Recombinant Inbred (RI) and Recombinant Congenic Mice Collaborative Cross (CC) Mice Congenic Mice Consomic Mice Conplastic Mice Outbred Mice Diversity Outbred (DO) Mice Nomenclature for Normal and Mutated Genes Spontaneous Mutations in Mice Non‐engineered Induced Mutations Chromosomal Aberration Nomenclature Genetically Engineered Mice Targeted, Endonuclease‐Mediated, Enhancer or Gene Trap, Transposon‐Induced, and Transgenic Mutations Summary Acknowledgments References

      9  4 Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect Introduction Basic Concepts of Defining a Mouse Model for a Human Disease Large‐Scale Mutagenesis Projects to Discover New Mouse Models From Human Polymorphism to Mouse Models New Mouse Genetic Tools Patient Derived Xenograft (PDX) Models Acknowledgments References

      10  5 Embryos, Placentas, and Neonates Introduction Four‐Dimensional Anatomy of the Developing Mouse Technical Considerations for Pathologic Evaluation of Developing Mice Pathologic Patterns in Mouse Embryos and Neonates Pathologic Patterns in Mouse Placenta Summary References

      11  6 Ciliopathies Introduction Motile Ciliopathies Sensory Ciliopathies