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Table of Contents
1 Cover
5 Preface
6 PART I: Prediabetes and the Diagnosis of Diabetes 1 “Is Prediabetes a Risk Factor or Is It a Disease?” What is prediabetes? Rationale for the diagnostic criteria for diabetes mellitus and prediabetes Epidemiology of prediabetes Pathogenesis of impaired fasting glucose and impaired glucose tolerance Screening recommendations for prediabetes Risk of progression from prediabetes to diabetes mellitus Microvascular complications associated with prediabetes Macrovascular complications and mortality associated with prediabetes Management of prediabetes Conclusion References 2 Early Diagnosis of Type 1 Diabetes – Useful or a Pyrrhic Victory? Introduction Pathogenesis of T1D: An Update in View of Defining Preventive Tools Prediction of T1D as the Basis for Disease Prevention Prevention of T1D: Current Status Conclusions Acknowledgments References 3 Reclassifying or Declassifying Diabetes? Can Clinical Characteristics Guide Classification and Treatment? The pathophysiology of hyperglycemia – type 1 vs type 2 diabetes Genetic and environmental influences on disease presentation Measuring insulin secretion Autoantibodies “Atypical” diabetes, glucose toxicity and the honeymoon period Cystic fibrosis‐related diabetes Novel approaches to reclassifying diabetes Conclusions Bibliography 4 How Should Secondary Causes of Diabetes Be Excluded? Introduction Hereditary haemochromatosis Cystic fibrosis‐related diabetes Pancreatic‐cancer‐associated diabetes Diabetes due to hormone excess Post‐transplantation diabetes mellitus (PTDM) Diabetes associated with atypical antipsychotic drug use Diabetes associated with HIV infection and its treatment Diabetes secondary to immunotherapy Monogenic forms of diabetes References 5 How to Screen Appropriately for Monogenic Diabetes Maturity onset diabetes of the young (MODY) Differentiating monogenic diabetes from type 1 diabetes Differentiating monogenic diabetes from type 2 diabetes When to screen for monogenic diabetes? Common forms of monogenic diabetes Conclusions References
7 PART II: Initial Evaluation and Management of Diabetes 6 Managing Gestational Diabetes During and After Pregnancy Introduction GDM diagnosis GDM management Conclusion References 7 What Is the Role of Self‐Monitoring in Diabetes? Is There a Role for Postprandial Glucose Monitoring? How Does Continuous Glucose Monitoring Integrate into Clinical Practice? Self‐monitoring of blood glucose SMGB in type 1 DM and insulin‐requiring T2DM patients SMBG in non‐insulin‐requiring T2DM Postprandial SMBG Continuous