David Shenk

The Forgetting: Understanding Alzheimer’s: A Biography of a Disease


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      THE FORGETTING

      Understanding Alzheimer’s:

      A Biography of a Disease

      DAVID SHENK

       COPYRIGHT

      William Collins

      An imprint of HarperCollinsPublishers Ltd. 1 London Bridge Street London SE1 9GF

       www.harpercollins.co.uk

      Published by Flamingo 2003

      First published in Great Britain by HarperCollinsPublishers 2002

      First published in the US by Doubleday 2001

      Copyright © David Shenk 2001

      David Shenk asserts the moral right to be identified as the author of this work

      Several of the names and identifying characteristics

      of the individuals depicted in this book have been changed to protect their privacy.

      All rights reserved under International and Pan-American Copyright Conventions. By payment of the required fees, you have been granted the nonexclusive, nontransferable right to access and read the text of this ebook on screen. No part of this text may be reproduced, transmitted, downloaded, decompiled, reverse engineered, or stored in or introduced into any information storage and retrieval system, in any form or by any means, whether electronic or mechanical, now known or hereinafter invented, without the express written permission of HarperCollins ebooks

      HarperCollinsPublishers has made every reasonable effort to ensure that any picture content and written content in this ebook has been included or removed in accordance with the contractual and technological constraints in operation at the time of publication

      Source ISBN: 9780006532088

      Ebook Edition © DECEMBER 2013 ISBN: 9780007439669 Version: 2016-09-09

       DEDICATION

       For Lucy

      CONTENTS

       Cover

       Title Page

       Prologue

       5. Irrespective of Age

       6. A Most Loving Brother

       PART II MIDDLE STAGE

       7. Fumbling for the Name of My Wife

       8. Back to Birth

       9. National Institute of Alzheimer’s

       10. Ten Thousand Feet, at Ten O’Clock at Night

       11. A World of Struldbruggs

       12. Humanize the Mouse

       13. We Hope to Radio Back to Earth Images of Beauty Never Seen

       PART III END STAGE

       14. Breakthrough?

       15. One Thousand Subtractions

       16. Things to Avoid

       17. The Mice Are Smarter

       Epilogue

       Resources for Patients and Families

       Sources

       Index

       Acknowledgments

       About the Author

       Praise

       About the Publisher

      LEAR: Does any here know me? This is not Lear.

       Does Lear walk thus, speak thus? Where are his eyes? Either his notion weakens, his discernings Are lethargied—Ha! Waking? ’Tis not so. Who is it that can tell me who I am?

      FOOL: Lear’s shadow.

      —William Shakespeare, King Lear

       PROLOGUE

      “When I was younger,” Mark Twain quipped near the end of his life, “I could remember anything, whether it had happened or not; but my faculties are decaying now and soon I shall be so I cannot remember any but the things that never happened.”

      At age seventy-two, Twain’s memory and wit were intact.