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Table of Contents
1 Cover
2 Preface
6 Section I: Scientific Basis of Clinical Autoimmune Liver Diseases 1 Introduction to the Physiology, Immunology and Pathology of the Liver and Biliary Tree Liver Cell Types and Organization Hepatic Metabolism Hepatic Transport Systems Drug Metabolism Bile Formation, Secretion and the Enterohepatic Circulation Death and Regeneration of Hepatocytes Cholangiocyte Reaction to Biliary Damage Protective Role of Biliary HCO3− Secretion Cholangiocytes and Immunity Biochemical Markers and Patterns of Hepatic Injury References 2 Concepts of Autoimmunity Relevant to Autoimmune Liver Diseases Introduction Role of Innate and Adaptive Immunity in Autoimmunity in the Context of the Liver as an Immune Organ Generation and Maintenance of Tolerance to Self‐antigens Risk Factors for Autoimmune Diseases Loss of Immune Tolerance to Autoantigens and Perpetuation of Autoimmune Diseases Prevention of Autoimmunity and Therapeutic Control of Autoimmune Diseases References 3 Genetics and Risk of Autoimmune Liver Diseases Introduction HLA Associations in Autoimmune Liver Disease Non‐HLA Associations in Autoimmune Liver Disease Conclusion References 4 Autoantibodies and Understanding of Autoimmune Liver Diseases Introduction Methods of Detection Anti‐nuclear Antibody Anti‐smooth Muscle and Anti‐actin Antibodies Anti‐liver‐kidney Microsomal Antibody Anti‐liver Cytosol Type 1 Antibody Anti‐soluble Liver Antigen Antibody Anti‐neutrophil Cytoplasmic Antibody Anti‐mitochondrial Antibody Anti‐asialoglycoprotein Receptor Antibody Indications for Autoimmune Liver Serology Testing Concluding Remarks References 5 Environmental Exposure and Risk in Autoimmune Liver Diseases Introduction Autoimmunity Primary Biliary Cholangitis Autoimmune Hepatitis Prospectus References
7 Section II: Autoimmune Liver Diseases and Their Clinical Correlation 6 Autoimmune Hepatitis Introduction Definition and Pathophysiology Epidemiology Presentation Diagnosis Treatment Prognosis References 7 Primary Biliary Cholangitis Introduction and Definition Epidemiology Etiopathogenesis Clinical Presentation Diagnosis Natural History Disease Course in the UDCA Era Risk Stratification Treatment