Table of Contents
1 Cover
6 Part I: Biological Basis of the Peripheral T‐cell Lymphomas 1 The Fundamentals of T‐cell Lymphocyte Biology Introduction General View of the Differentiation and Function of T Lymphocytes The T‐cell System as a Frame for Peripheral T‐cell Lymphoma: Taking Plasticity into Account Must Reads References 2 Mechanisms of T‐cell Lymphomagenesis Introduction Oncogenic Events in the Transformation of T or Natural Killer Cells Conclusion Acknowledgement Must Reads References 3 Epigenetics of T‐cell Lymphoma Introduction Epigenetic Pathways Altered in T‐cell Lymphoma Epigenetic Changes Within Specific T‐cell Lymphoma Subtypes Established and Emerging Drugs Targeting the T‐cell Lymphoma Epigenome Combination Therapies Involving Epigenetic Targeting Agents Future Directions Must Reads References 4 Animal Models of T‐cell Lymphoma Introduction Angioimmunoblastic T‐cell Lymphoma Anaplastic Large T‐cell Lymphoma Human T‐cell Lymphotropic Virus Type 1 Adult T‐cell Leukemia/Lymphoma Cutaneous T‐cell Lymphoma Enteropathy‐associated T‐cell Lymphoma Conclusion Must Reads References
7 Part II: Epidemiology and Classification of the PTCL 5 Geographic Distribution of the Peripheral T‐cell Lymphomas Historical Perspective Epidemiology Conclusion Must Reads References 5.A 2017 World Health Organization Classification of Mature T- and NK-cell Neoplasms 6 Classification of the Peripheral T‐cell Lymphomas Introduction Angioimmunoblastic T‐cell Lymphoma and Other Nodal Lymphomas of T follicular Helper Cell Origin Peripheral T‐cell Lymphoma Not Otherwise Specified Anaplastic Large‐cell Lymphomas Adult T‐cell Leukemia/Lymphoma Intestinal T‐cell Lymphomas Hepatosplenic T‐cell Lymphoma Mycosis Fungoides Sézary Syndrome Primary Cutaneous CD30‐positive T‐cell Lymphoproliferative Disorders Primary Cutaneous Gamma–Delta T‐cell Lymphoma Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T‐cell Lymphoma (Provisional) Primary Cutaneous CD4+ Small/Medium T‐Cell Lymphoproliferative Disorder (Provisional) Primary Cutaneous Acral CD8+ T‐cell Lymphoma (Provisional) Large Granular Lymphocytic Leukemia T‐cell Prolymphocytic Leukemia NK‐cell Lymphomas Must Reads References 7 Molecular Classification of the Peripheral T‐cell Lymphomas Introduction T‐cell Development and Activation: An Overview T‐cell Receptor Signaling Derivation of Diagnostic Signatures for Molecular Classification