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Progress in Tumor Research
Vol. 44
Series Editor
Rolf A. Stahel Zurich
Solange Peters Lausanne
Advances in Radiation Therapy
Volume Editors
M. Guckenberger Zurich
S.E. Combs Munich
D. Zips Tübingen
24 figures, 20 in color, and 4 tables, 2018
Progress in Tumor Research
Formerly published as ‘Progress in Experimental Tumor Research’
| _______________________M. Guckenberger, MDDepartment of Radiation OncologyUniversity Hospital Zurich (USZ)Rämistrasse 100CH–8091 Zurich (Switzerland) | _______________________S.E. Combs, MDDepartment of Radiation OncologyTechnische Universität München (TUM)Klinikum rechts der IsarDE–81675 München (Germany) |
| _______________________D. Zips, MDEberhard Karls Universität TübingenRadioonkologieHoppe-Seyler-Straße 3DE–72076 Tübingen (Germany) |
Library of Congress Cataloging-in-Publication Data
Names: Guckenberger, M. (Matthias), 1976- editor. | Combs, S. E. (Stephanie Elisabeth), editor. | Zips, D. (Daniel), editor.
Title: Advances in radiation therapy / volume editors, M. Guckenberger, S.E. Combs, D. Zips.
Other titles: Advances in radiation therapy (Guckenberger) | Progress in tumor research ; v. 44. 2296-1895
Description: Basel ; New York : Karger, 2018. | Series: Progress in tumor research, ISSN 2296-1895 ; vol. 44 | Includes bibliographical references and indexes.
Identifiers: LCCN 2018011881| ISBN 9783318063615 (hard cover : alk. paper) | ISBN 9783318063622 (eBook)
Subjects: | MESH: Neoplasms--radiotherapy | Radiotherapy | Elementary Particles--therapeutic use | Radiotherapy Planning, Computer-Assisted
Classification: LCC RC271.R3 | NLM QZ 269 | DDC 616.99/40642--dc23 LC record available
at https://lccn.loc.gov/2018011881
Bibliographic Indices. This publication is listed in bibliographic services, including MEDLINE/PubMed, Thomson Reuters indices.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2018 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
Printed on acid-free and non-aging paper (ISO 9706)
ISSN 2296–1895
e-ISSN 2296–1887
ISBN 978–3–318–06361–5
e-ISBN 978–3–318–06362–2
Contents
Guckenberger, M. (Zurich); Combs, S.E. (Munich); Zips, D. (Tübingen)
Eckert, F.; Huber, S. (Tübingen)
Imageable Biomarkers for Radiotherapy Response
Woliner-van der Weg, W.; Span, P.N.; Braam, P.M.; Bussink, J. (Nijmegen)
Targeting Tumor Microenvironment and Metabolism to Overcome Radiation Resistance
Sharma, A.; Pruschy, M. (Zurich)
Imaging for Target Volume Definition and Response Assessment in Lung Cancer
De Ruysscher, D.; van Elmpt, W. (Maastricht)
Advances in Technology and Its Application: Radiotherapy Treatment Planning
Alber, M. (Heidelberg)
Stereotactic Body Radiotherapy
Guckenberger, M. (Zurich)
Clinical Rationale and Indications for Particle Therapy
Dreher, C.; Combs, S.E. (Munich)
Advances in Radiation Biology of Particle Irradiation
Helm, A.; Tinganelli, W.; Durante, M. (Trento)
Preclinical Mouse Models for the Evaluation of Novel Techniques in Particle Therapy
Schmid, T.E. (Munich); Multhoff, G. (Neuherberg)
Clinically relevant progress has been made in the diagnosis and treatment of cancer in recent decades; however, this progress varies substantially between cancer types and between countries with variable access to health care resources. Five-year survival rates have improved beyond 50% for breast cancer and colon cancer, whereas lung cancer is associated with poor survival of <20% and only very little progress has been made with overall