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Magnetic Nanoparticles in Human Health and Medicine


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of 11.1 nm, it deviates from the law corresponding to the bulk material. In the case of magnetite (Fe3O4) nanoparticles coated with oleic acid, Caizer (2003b) shows that the law is well verified for T2 instead of T3/2, and the constant of Ms(0) in Eq. (1.12) becomes in this case a function of temperature:

      (1.13)equation

      However, in the case of Mn0.6Fe2.4O4 nanoparticles coated with oleic acid (Caizer 2005a), it is found that is verified in the law of Eq. (1.12), but Ms(0) is no longer a constant but is temperature‐dependent according to the formula:

      In this equation, n is the concentration of the nanoparticles, and ci are constants whose value is known, resulting from the fitting of the experimental data. In Figure 1.6b is shown the dependence on MsatT in this case, where the deviation is highlighted: (α) is the curve for bulk and (β) is the curve for nanoparticles. These results as well as others (Caizer 2002) show that T3/2 valid in the case of bulk magnetic material is no longer verified in the case of magnetic nanoparticles, and there are different interpretations for this.

Schematic illustrations of (a) Specific saturation magnetization as a function of the mean diameter of nanocrystallites. (b) Core-shell pattern of the spherical nanoparticle.

      Source: Caizer and Stefanescu (2002). Reprinted by permission from IOP Publishing.

      (b) Core‐shell pattern of the spherical nanoparticle.

      Source: Caizer (2016). Springer Nature.

      To conclude, if in the case of bulk magnetic material, the saturation magnetization is a well‐defined value, being a material parameter, characteristic of the substance type, in the case of nanoparticles it is generally smaller, and decreases with the decrease in diameter to nanometers size. This is a very important aspect that must be taken into account in biomedical applications. Thus, in order not to introduce errors in the application of magnetic nanoparticles, it is recommended, before conducting any experiment, to determine/measure the saturation magnetization of the nanoparticles, and also the variation of saturation magnetization with temperature, if there is such a dependency in the targeted application.

      1.1.5 Magnetic Anisotropy

      Experimentally, it was found that in the case of ferro‐ or ferrimagnetic crystalline materials, there is a dependence of the magnetization of the single crystal on the crystallographic directions. The dependence of the magnetization of the crystalline magnetic material on the crystallographic axes determines the magnetocrystalline anisotropy (Kneller 1962; Caizer 2004a, 2019). Thus, the magnetization curves that are obtained in the same external magnetic field depend on the direction in which the crystalline material is magnetized. This type of magnetic anisotropy is characteristic of all bulk single crystalline (ferro‐ or ferromagnetic) magnetic materials (Fe, Co, Ni, Cd, their alloys, Fe oxides [Fe3O4, γ‐Fe2O3], etc.).

Schematic illustrations of (a) the crystallographic systems for Ni-single crystal. (b) Room temperature magnetization curves for Ni along the easy ([111]) and hard ([100]) direction.

      Source: Caizer (2016). Reprinted by permission from Springer Nature;

      (b) Room temperature magnetization curves for Ni along the easy ([111]) and hard ([100]) direction.

      Source: Based on Wijn (1986).

      In the case of bulk ferromagnetic monocrystalline material with cubic symmetry, the energy of magnetocrystalline anisotropy can be determined with the following formula: