Fiuza‐Luces C, Santos‐Lozano A, Joyner M, et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat Rev Cardiol. 2018. doi:10.1038/s41569‐018‐0065‐1.
22 22. Cadore EL, Izquierdo M. Exercise interventions in polypathological aging patients that coexist with diabetes mellitus: improving functional status and quality of life. Age (Omaha). 2015; 37(3). doi:10.1007/s11357‐015‐9800‐2.
23 23. Westaway K, Blacker N, Shute R, et al. Combination psychotropic medicine use in older adults and risk of hip fracture. Aust Prescr. 2019; 42(3):93–96. doi:10.18773/austprescr.2019.011.
24 24. Mavros Y, Gates N, Wilson GC, et al. Mediation of cognitive function improvements by strength gains after resistance training in older adults with mild cognitive impairment: outcomes of the study of mental and resistance training. J Am Geriatr Soc. 2017; 65(3):550–559. doi:10.1111/jgs.14542.
25 25. Pereira NL, Weinshilboum RM. Cardiovascular pharmacogenomics and individualized drug therapy. Nat Rev Cardiol. 2009; 6(10):632–638. doi:10.1038/nrcardio.2009.154.
26 26. Bouchard C, Blair SN, Church TS, et al. Adverse metabolic response to regular exercise: Is it a rare or common occurrence? PLoS One. 2012. doi:10.1371/journal.pone.0037887.
27 27. Bouchard C, Rankinen T. Individual differences in response to regular physical activity. Med Sci Sports Exerc. 2001; 33(6 Suppl):S446–51; discussion S452–3. http://www.ncbi.nlm.nih.gov/pubmed/11427769. Accessed August 3, 2019.
28 28. Álvarez C, Ramírez‐Campillo R, Ramírez‐Vélez R, et al. Metabolic effects of resistance or high‐intensity interval training among glycemic control‐nonresponsive children with insulin resistance. Int J Obes. 2018. doi:10.1038/ijo.2017.177.
29 29. Alvarez C, Ramírez‐Campillo R, Ramírez‐Vélez R, Izquierdo M. Effects of 6‐weeks high‐intensity interval training in schoolchildren with insulin resistance: Influence of biological maturation on metabolic, body composition, cardiovascular and performance non‐responses. Front Physiol. 2017; 8(JUN). doi:10.3389/fphys.2017.00444.
30 30. Álvarez C, Ramírez‐Campillo R, Ramírez‐Vélez R, Izquierdo M. Effects and prevalence of nonresponders after 12 weeks of high‐intensity interval or resistance training in women with insulin resistance: A randomized trial. J Appl Physiol. 2017; 122(4). doi:10.1152/japplphysiol.01037.2016.
31 31. Ramírez‐Vélez R, Lobelo F, Izquierdo M. Exercise for disease prevention and management: a precision medicine approach. J Am Med Dir Assoc. 2017; 18(7). doi:10.1016/j.jamda.2017.04.012.
32 32. Boulé NG, Weisnagel SJ, Lakka TA, et al. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care. 2005; 28(1):108–114. doi:10.2337/diacare.28.1.108.
33 33. Sparks LM. Exercise training response heterogeneity: physiological and molecular insights. Diabetologia. 2017; 60(12):2329–2336. doi:10.1007/s00125‐017‐4461‐6.
34 34. Lee IM, Shiroma EJ, Kamada M, Bassett DR, Matthews CE, Buring JE. Association of step volume and intensity with all‐cause mortality in older women. JAMA Internal Medicine. 2019; 179:1105–1112. doi:10.1001/jamainternmed.2019.0899.
35 35. Justice JN, Cesari M, Seals DR, Shively CA, Carter CS. Comparative approaches to understanding the relation between aging and physical function. Journals Gerontol – Ser A Biol Sci Med Sci. 2016. doi:10.1093/gerona/glv035.
36 36. Ramírez‐Vélez R, Correa‐Bautista JE, García‐Hermoso A, Cano CA, Izquierdo M. Reference values for handgrip strength and their association with intrinsic capacity domains among older adults. J Cachexia Sarcopenia Muscle. 2019; 10(2):278–286. doi:10.1002/jcsm.12373.
37 37. Fiatarone Singh MA. Tailoring assessments and prescription in cardiac rehabilitation for older adults: the relevance of geriatric domains. Clin Geriatr Med. 2019; 35(4):423–443. doi:10.1016/j.cger.2019.07.013.
38 38. Odden MC, Peralta CA, Haan MN, Covinsky KE. Rethinking the association of high blood pressure with mortality in elderly adults: The impact of frailty. Arch Intern Med. 2012. doi:10.1001/archinternmed.2012.2555.
39 39. Beard JR, Officer A, De Carvalho IA, et al. The World report on ageing and health: A policy framework for healthy ageing. Lancet. 2016. doi:10.1016/S0140‐6736(15)00516‐4.
40 40. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. Journals Gerontol Ser A Biol Sci Med Sci. 2001. doi:10.1093/gerona/56.3.m146.
41 41. Rodríguez‐Mañas L, Féart C, Mann G, et al. Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition‐consensus conference project. Rodríguez‐Mañas L, Féart C, Mann G, et al. J Gerontol A Biol Sci Med Sci. 2013. doi:10.1093/gerona/gls119.
42 42. Kojima G. Prevalence of Frailty in nursing homes: a systematic review and meta‐analysis. J Am Med Dir Assoc. 2015; 16(11):940–945. doi:10.1016/j.jamda.2015.06.025.
43 43. Kojima G. Frailty as a predictor of nursing home placement among community‐dwelling older adults: a systematic review and meta‐analysis. J Geriatr Phys Ther. 2018. doi:10.1519/JPT.0000000000000097.
44 44. Buckinx F, Reginster JY, Petermans J, et al. Relationship between frailty, physical performance and quality of life among nursing home residents: the SENIOR cohort. Aging Clin Exp Res. 2016; 28(6):1149–1157. doi:10.1007/s40520‐016‐0616‐4.
45 45. Espeland MA, Gill TM, Guralnik J, et al. Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE‐P) trial. J Gerontol A Biol Sci Med Sci. 2007; 62(11):1237–1243. doi:10.1093/gerona/62.11.1237.
46 46. Bortz WM. Redefining human aging. J Am Geriatr Soc. 1989; 37(11):1092–1096. doi:10.1111/j.1532‐5415.1989.tb06926.x.
47 47. Fleg JL, Lakatta EG. Role of muscle loss in the age‐associated reduction in VO2 max. J Appl Physiol. 1988; 65(3):1147–1151. doi:10.1152/jappl.1988.65.3.1147.
48 48. Izquierdo M, Häkkinen K, Antón A, et al. Maximal strength and power, endurance performance, and serum hormones in middle‐aged and elderly men. Med Sci Sports Exerc. 2001; 33(9). doi:10.1097/00005768‐200109000‐00022.
49 49. Aagaard P, Suetta C, Caserotti P, Magnusson SP, Kjær M. Role of the nervous system in sarcopenia and muscle atrophy with aging: Strength training as a countermeasure. Scand J Med Sci Sport. 2010. doi:10.1111/j.1600‐0838.2009.01084.x.
50 50. Evans WJ, Frontera WR, Roubenoff R, Hughes VA, Singh MAF. Longitudinal changes in body composition in older men and women: role of body weight change and physical activity. Am J Clin Nutr. 2018. doi:10.1093/ajcn/76.2.473.
51 51. Klitgaard H, Mantoni M, Schiaffino S, et al. Function, morphology and protein expression of ageing skeletal muscle: a cross‐sectional study of elderly men with different training backgrounds. Acta Physiol Scand. 1990; 140(1):41–54. doi:10.1111/j.1748‐1716.1990.tb08974.x.
52 52. Reid KF. Skeletal muscle power: a critical determinant of physical functioning in older adults. Pan‐Pac Entomol. 2012. doi:10.1097/JES.0b013e31823b5f13.Skeletal.
53 53. Izquierdo M, Ibañez J, Gorostiaga E, et al. Maximal strength and power characteristics in isometric and dynamic actions of the upper and lower extremities in middle‐aged and older men. Acta Physiol Scand. 1999; 167(1). doi:10.1046/j.1365‐201x.1999.00590.x.
54 54. Orr R, De Vos NJ, Singh NA, Ross DA, Stavrinos TM, Fiatarone‐Singh MA. Power training improves balance in healthy older adults. Journals Gerontol – Ser A Biol Sci Med Sci. 2006; 61(1):78–85. doi:10.1093/gerona/61.1.78.
55 55. Akbari M, Mousavikhatir R, Beas‐Jiménez J de D, et al. Effects of aging on Type II muscle fibers: a systematic review of the literature. J Appl Physiol. 2014. doi:10.1002/acr.20642.
56 56. Harridge SDR, Lazarus NR. Physical activity, aging, and physiological function. Physiology (Bethesda). 2017; 32(2):152–161. doi:10.1152/physiol.00029.2016.
57 57.