2008–2013; PFS: 22% in 2000–2007 to 32% in 2008–2013, P = .003). Two‐year treatment‐related mortality ranged remained unchanged over time (33–35%). Higher comorbidity and myeloablative conditioning were associated with higher mortality rates.102
Again, undertaking CGA is crucial in selecting the candidates for transplantation.
Key points
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by dysplasia, ineffective haematopoiesis, and potential risk of transformation into acute leukaemia.
In MDS, the important predictors for overall prognoses are cytogenetic abnormalities, percentage of myeloblasts in the bone marrow, and number of lineages that exhibit cytopenias.
Because the defect in MDS occurs in an early haematopoietic precursor, allogeneic transplant represents a potentially curative option.
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