Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin. 2004; 20(5):607–17. doi:10.1185/030079904125003467.
26 26. Irwin GM. Erectile dysfunction. Prim Care. 2019; 46(2):249–255. doi:10.1016/j.pop.2019.02.006.
27 27. Alexandre B, Lemaire A, Desvaux P, Amar E. Intracavernous injections of prostaglandin E1 for erectile dysfunction: patient satisfaction and quality of sex life on long‐term treatment. J Sex Med. 2007; 4(2):426–31. doi:10.1111/j.1743‐6109.2006.00260.x.
28 28. Urciuoli R, Cantisani TA, Carlini M, Giuglietti M, Botti FM. Prostaglandin E1 for treatment of erectile dysfunction. The Cochrane Database of Systematic Reviews. 2004;(2):Cd001784. doi:10.1002/14651858.CD001784.pub2.
29 29. Phillips RL Jr, Slaughter JR. Depression and sexual desire. Am Fam Physician. 15 2000; 62(4):782–6.
30 30. Wu FC, Tajar A, Beynon JM, et al. Identification of late‐onset hypogonadism in middle‐aged and elderly men. N Engl J Med. 2010; 363(2):123–35. doi:10.1056/NEJMoa0911101.
31 31. Huhtaniemi IT. Andropause – lessons from the European Male Ageing Study. Ann Endocrinol (Paris). 2014; 75(2):128–31. doi:10.1016/j.ando.2014.03.005.
32 32. Tajar A, Huhtaniemi IT, O’Neill TW, et al. Characteristics of androgen deficiency in late‐onset hypogonadism: results from the European Male Aging Study (EMAS). J Clin Endocrinol Metab. 2012; 97(5):1508–16. doi:10.1210/jc.2011‐2513.
33 33. Wu FC, Tajar A, Pye SR, et al. Hypothalamic‐pituitary‐testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008; 93(7):2737–45. doi:10.1210/jc.2007‐1972.
34 34. Elliott J, Kelly SE, Millar AC, et al. Testosterone therapy in hypogonadal men: a systematic review and network meta‐analysis. BMJ open. 2017; 7(11):e015284. doi:10.1136/bmjopen‐2016‐015284.
35 35. Snyder PJ, Bhasin S, Cunningham GR, et al. Effects of testosterone treatment in older men. N Engl J Med. 2016; 374(7):611–24. doi:10.1056/NEJMoa1506119.
36 36. Singh P. Andropause: Current concepts. Indian J Endocrinol Metab. 2013; 17(Suppl 3):S621–9. doi:10.4103/2230‐8210.123552.
37 37. Beal‐Lloyd D, Groh CJ. Dialysis and sexuality. Nephrol Nurs. J 2012; 39(4):281–3; quiz 284.
38 38. Lee DM, Tetley J, Pendleton N. Urinary incontinence and sexual health in a population sample of older people. BJU Int. 2018; 122(2):300–308. doi:10.1111/bju.14177.
39 39. Moreira ED, Glasser DB, King R, Duarte FG, Gingell C. Sexual difficulties and help‐seeking among mature adults in Australia: results from the Global Study of Sexual Attitudes and Behaviours. Sexual Health. 2008; 5(3):227–34.
40 40. Laumann EO, Waite LJ. Sexual dysfunction among older adults: prevalence and risk factors from a nationally representative U.S. probability sample of men and women 57–85 years of age. J Sex Med. 2008; 5(10):2300–11. doi:10.1111/j.1743‐6109.2008.00974.x.
41 41. Meiri R, Rosenbaum TY, Kalichman L. Sexual Function before and after total hip replacement: narrative review. Sexual Medicine. 2014; 2(4):159–67. doi:10.1002/sm2.35.
42 42. Crowley SA, Foley SM, Wittmann D, et al. Sexual health concerns among cancer survivors: testing a novel information‐need measure among breast and prostate cancer patients. J Cancer Educ. 2016; 31(3):588–94. doi:10.1007/s13187‐015‐0865‐5.
43 43. Loi M, Wortel RC, Francolini G, Incrocci L. Sexual function in patients treated with stereotactic radiotherapy for prostate cancer: a systematic review of the current evidence. J Sex Med. 2019;doi:10.1016/j.jsxm.2019.05.019.
44 44. Lardas M, Liew M, van den Bergh RC, et al. Quality of life outcomes after primary treatment for clinically localised prostate cancer: a systematic review. Eur Urol. 2017; 72(6):869–885. doi:10.1016/j.eururo.2017.06.035.
45 45. Griebling TL. Sexuality and aging: a focus on lesbian, gay, bisexual, and transgender (LGBT) needs in palliative and end of life care. Current Opinion in Supportive and Palliative Care. 2016; 10(1):95–101. doi:10.1097/spc.0000000000000196.
46 46. Stabile C, Goldfarb S, Baser RE, et al. Sexual health needs and educational intervention preferences for women with cancer. Breast Cancer Res Treat. 2017; 165(1):77–84. doi:10.1007/s10549‐017‐4305‐6.
47 47. Wilkins JM. More than capacity: alternatives for sexual decision making for individuals with dementia. Gerontologist. 2015; 55(5):716–23. doi:10.1093/geront/gnv098.
48 48. de Medeiros K, Rosenberg PB, Baker AS, Onyike CU. Improper sexual behaviors in elders with dementia living in residential care. Dement Geriatr Cogn Disord. 2008; 26(4):370–7. doi:10.1159/000163219.
49 49. Rosen T, Lachs MS, Pillemer K. Sexual aggression between residents in nursing homes: literature synthesis of an underrecognized problem. J Am Geriatr Soc. 2010; 58(10):1970–9. doi:10.1111/j.1532‐5415.2010.03064.x.
50 50. Tucker I. Management of inappropriate sexual behaviors in dementia: a literature review. Int Psychogeriatr. 2010; 22(5):683–92. doi:10.1017/s1041610210000189.
51 51. Ports KA, Barnack‐Tavlaris JL, Syme ML, Perera RA, Lafata JE. Sexual health discussions with older adult patients during periodic health exams. J Sex Med. 2014; 11(4):901–908. doi:10.1111/jsm.12448.
52 52. CDC. Sexually transmitted disease surveillance 2017. Accessed July 18, 2019. https://wwwcdcgov/std/stats17/tochtm. 2017.
53 53. Bodley‐Tickell AT, Olowokure B, Bhaduri S, et al. Trends in sexually transmitted infections (other than HIV) in older people: analysis of data from an enhanced surveillance system. Sex Transm Infect. 2008; 84(4):312–7. doi:10.1136/sti.2007.027847.
54 54. CDC. HIV Surveillance Report. 2016. https://wwwcdcgov/hiv/pdf/library/reports/surveillance/cdc‐hiv‐surveillance‐report‐2016‐vol‐28pdf.
55 55. Ward EG, Disch WB, Schensul JJ, Levy JA. Understanding low‐income, minority older adult self‐perceptions of HIV risk. J Assoc Nurses AIDS Care. 2011; 22(1):26–37. doi:10.1016/j.jana.2010.05.002.
56 56. Reece M, Herbenick D, Schick V, Sanders SA, Dodge B, Fortenberry JD. Condom use rates in a national probability sample of males and females ages 14 to 94 in the United States. J Sex Med. 2010; 7 Suppl 5:266–76. doi:10.1111/j.1743‐6109.2010.02017.x.
57 57. Adolescents. PoAGfAa. Guidelines for the use of antiretroviral agents and adolescents with HIV. Department of Health and Human Services. 2016. http://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf.
58 58. Fleishman JM, Crane B, Koch PB. Correlates and predictors of sexual satisfaction for older adults in same‐sex relationships. J Homosex. 2019; 67(14):1–25. doi:10.1080/00918369.2019.1618647.
59 59. Klitzman RL, Greenberg JD. Patterns of communication between gay and lesbian patients and their health care providers. J Homosex. 2002; 42(4):65–75. doi:10.1300/J082v42n04_04.
60 60. Abner EL, Teaster PB, Mendiondo MS, et al. Victim, allegation, and investigation characteristics associated with substantiated reports of sexual abuse of adults in residential care settings. Journal of Interpersonal Violence. 2019; 34(19):3995–4019. doi:10.1177/0886260516672051.
61 61. Speck PM, Hartig MT, Likes W, et al. Case series of sexual assault in older persons. Clin Geriatr Med. 2014; 30(4):779–806. doi:10.1016/j.cger.2014.08.007.
CHAPTER 6 Ageing of the brain
Marco Canevelli1,2 and Luca Marsili3
1 Department of Human Neuroscience, Sapienza University, Rome, Italy
2