Life Sci VC (2019). Venturing a perspective on the drug pricing debate. https://lifescivc.com/2019/12/venturing‐a‐perspective‐on‐the‐drug‐pricing‐debate (accessed 29 September 2021).
13 13 Stoner, I. (2019). Biopharma has abandoned antibiotic development. Here's why we did, too. https://endpts.com/biopharma‐has‐abandoned‐antibiotic‐development‐heres‐why‐we‐did‐too (accessed 29 September 2021).
14 14 McCarthy, J. (2019). Big pharma sinks to the bottom of U.S. industry rankings. https://news.gallup.com/poll/266060/big‐pharma‐sinks‐bottom‐industry‐rankings.aspx (accessed 29 September 2021).
15 15 Lederman, L. (2019). The ever more pressing problem of science literacy. In: Learning to Live Together: Promoting Social Harmony (ed. J. Kelso), 139–147. Cham: Springer.
16 16 Alltucker, K. (2019). Struggling to stay alive: rising insulin prices cause diabetics to go to extremes https://www.usatoday.com/in‐depth/news/50‐states/2019/03/21/diabetes‐insulin‐costs‐diabetics‐drug‐prices‐increase/3196757002 (accessed 29 September 2021).
17 17 Smythe, C. and Geiger, K.(2015). Shkreli, drug price gouger, denies fraud and posts bail. https://www.bloomberg.com/features/2015‐martin‐shkreli‐securities‐fraud (accessed 29 September 2021).
18 18 Ramsey, L. (2018). The rise and fall of Theranos, the blood‐testing startup that went from Silicon Valley darling to facing fraud charges. https://www.businessinsider.com/the‐history‐of‐silicon‐valley‐unicorn‐theranos‐and‐ceo‐elizabeth‐holmes‐2018‐5 (accessed 29 September 2021).
19 19 Ekins, S., Mottin, M., Ramos, P. et al. (2020). Déjà vu: stimulating open drug discovery for SARS‐CoV‐2. Drug Discov. Today 25 (5): 928–941.
20 20 Dubois, M., Ardin, C., André, F. et al. (2019). The revolution of immuno‐oncology therapy: review of immune checkpoint inhibitors efficacy. Med. Sci. (Paris) 35 (12): 937–945.
21 21 Yu, J.X., Hubbard‐Lucey, V.M., and Tang, J. (2019). Immuno‐oncology drug development goes global. Nat. Rev. Drug Discov. 18: 899–900.
22 22 Owen, C., Berinstein, N.L., Christofides, A., and Sehn, L.H. (2019). Review of Bruton tyrosine kinase inhibitors for the treatment of relapsed or refractory mantle cell lymphoma. Curr. Oncol. 26 (2): e233–e240.
23 23 Zinman, B., Wanner, C., Lachin, J.M. et al. (2015). Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N. Engl. J. Med. 373 (22): 2117–2128.
24 24 Pontali, E., Raviglione, M.C., Migliori, G.B., and the writing group members of the Global TB Network Clinical Trials Committee (2019). Regimens to treat multidrug‐resistant tuberculosis: past, present and future perspectives. Eur. Respir. Rev. 28: 1–7.
25 25 Morgan, P., Brown, D.G., Lennard, S. et al. (2018). Impact of a five‐dimensional framework on R&D productivity at AstraZeneca. Nat. Rev. Drug Discov. 17: 167–181.
26 26 Disney, M.D., Dwyer, B.G., and Childs‐Disney, J.L. (2018). Drugging the RNA world. Cold Spring Harb. Perspect. Biol. 10: 1–15.
27 27 Dang, C.V., Reddy, E.P., Shokat, K.M., and Soucek, L. (2017). Drugging the ‘Undruggable’ cancer targets. Nat. Rev. Cancer 17: 502–508.
28 28 Netea‐Maiera, R.T., Plantingaa, T.S., van de Veerdonka, F.L. et al. (2016). Modulation of Inflammation by Autophagy: Consequences for Human Disease. Autophagy 12 (2): 245–260.
29 29 Bondeson, D.P. and Crews, C.M. (2017). Targeted protein degradation by small molecules. Annu. Rev. Pharmacol. Toxicol. 57: 107–123.
30 30 Chamberlain, P.P. and Haman, L.G. (2019). Development of targeted protein degradation therapeutics. Nat. Chem. Biol. 15: 937–944.
31 31 Edmondson, S.D., Yanga, B., and Fallan, C. (2019). Proteolysis targeting chimeras (PROTACs) in ‘Beyond Rule‐of‐Five’ chemical space: recent progress and future challenges. Bioorg. Med. Chem. Lett. 29: 1555–1564.
32 32 Campos, K.R., Coleman, P.J., Alvarez, J.C. et al. (2019). The importance of synthetic chemistry in the pharmaceutical industry. Science 363 (6424).
33 33 Blakemore, D.C., Castro, L., Churcher, I. et al. (2018). Organic synthesis provides opportunities to transform drug discovery. Nat. Chem. 10: 383–394.
34 34 Taylor, A.P., Robinson, R.P., Fobian, Y.M. et al. (2016). Modern advances in heterocyclic chemistry in drug discovery. Org. Biomol. Chem. 14: 6611–6637.
35 35 Boström, J., Brown, D.G., Young, R.G., and Keserü, G.M. (2018). Expanding the medicinal chemistry synthetic toolbox. Nat. Rev. Drug Discov. 17: 709–727.
36 36 Denmark, S.E. (2018). Organic synthesis: wherefrom and whither? (some very personal reflections). Isr. J. Chem. 58 (1–2): 61–72.
37 37 Schneider, G. (2018). Automating drug discovery. Nat. Rev. Drug Discov. 17: 97–113.
38 38 Peplow, M. (2019). Automation for the people: training a new generation of chemists in data‐driven synthesis. https://cen.acs.org/content/cen/articles/97/i42/Automation‐people‐Training‐new‐generation.html (accessed 29 September 2021).
39 39 Rudroff, F., Mihovilovic, M.D., Gröger, H. et al. (2018). Opportunities and challenges for combining chemo‐ and biocatalysis. Nat. Biocatal. 1: 12–22.
40 40 Halford, B. (2019). Amping up the pharma lab: drug companies explore the potential of electrochemistry. https://cen.acs.org/synthesis/medicinal‐chemistry/Amping‐pharma‐lab‐Drug‐companies/97/i43 (accessed 29 September 2021).
41 41 Plutschack, M.B., Pieber, B., Gilmore, K., and Seeberger, P.H. (2017). The Hitchhiker's guide to flow chemistry. Chem. Rev. 117: 11796–11893.
42 42 Wang, B., Perea, M.A., and Sarpong, R. (2020). Transition metal‐mediated C–C single bond cleavage: making the cut in total synthesis. Angew. Chem., Int. Ed. Engl. https://doi.org/10.1002/anie.201915657.
43 43 Prier, C.K. and MacMillan, D.W.C. (2018). Dual photoredox catalysis: the merger of photoredox catalysis with other catalytic activation modes. In: Visible Light Photocatalysis in Organic Chemistry (eds. R.J. Stephenson, T.P. Yoon and D.W.C. MacMillan), 299–334. Wiley & Sons.
44 44 Panteleeva, J., Gao, H., and Ji, L. (2018). Recent applications of machine learning in medicinal chemistry. Bioorg. Med. Chem. Lett. 28: 2807–2815.
45 45 Riley, P. (2019). Three pitfalls to avoid in machine learning. Nature 527: 27–28.
46 46 Friedman, T.L. (2005). The World is Flat: A Brief History of the Twenty‐first Century. New York: Farrar, Straus and Giroux.
47 47 Jordan, A.M. (2018). Artificial intelligence in drug design: the storm before the calm? ACS Med. Chem. Lett. 18: 1150–1152.
48 48 Daniel, B.K. (2019). Big data and data science: a critical review of issues for educational research. Br. J. Educ. Technol. 50 (1): 101–113.
49 49 Petriglieri, G., Ashford, S.J., and Wrzesniewski, A. (2019). Agony and ecstasy in the gig economy: cultivating holding environments for precarious and