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Drug Transporters


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transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 2004; 447 (5):619–628.

      30 [30] Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T. Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes. J Clin Endocr Metab 2002; 87:3500–3503.

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      42 [42] Seward DJ, Koh AS, Boyer JL, Ballatori N. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha‐OSTbeta. J Biol Chem 2003; 278 (30):27473–27482.

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      45 [45] Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV, Deeley RG. Overexpression of a transporter gene in a multidrug‐resistant human lung cancer cell line. Science 1992; 258:1650–1654.

      46 [46] Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin‐resistant human cancer cell lines with decreased drug accumulation. Cancer Res 1996; 56:4124–4129.

      47 [47] Uchiumi T, Hinoshita E, Haga S, Nakamura T, Tanaka T, Toh S, Furukawa M, Kawabe T, Wada M, Kagotani K, Okumura K, Kohno K, Akiyama S, Kuwano M. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin‐resistant cancer cells with decreased ATP‐dependent drug transport. Biochem. Biophys Res Commun 1998; 252:103–110.

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      50 [50] Kuss BJ, O'Neill GM, Eyre H, Doggett NA, Callen DF, Davey RA. ARA, a novel ABC transporter, is located at 16p13.1, is deleted in inv(16) leukemias, and is shown to be expressed in primitive hematopoietic precursors. Genomics 1998; 51:[455–458.

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      57 [57] Lapenta V, Sossi V, Gosset P, Vayssettes C, Vitali T, Rabatel N, Tassone F, Blouin JL, Scott HS, Antonarakis SE, Créau N, Brahe C. Construction of a 2.5‐Mb integrated physical and gene map of distal 21q22.3. Genomics 1998; 49 (1):1–13. doi: 10.1006/geno.1997.5185. PMID: 9570943.

      58 [58] Shayeghi M, Latunde‐Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT. Identification of an intestinal heme transporter. Cell 2005; 122 (5):789–801. doi: 10.1016/j.cell.2005.06.025. PMID: 16143108.

      Megan L. Koleske1, Xiaomin Liang2,