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Applied Smart Health Care Informatics


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profiles, such as genomics, epigenomics, and transcriptomics may provide new insights into discovering some unknown genomic mechanisms involved in cancer and other related complex diseases. The alterations of multiple omics, including gene mutations, epigenetic changes, and gene regulation modifications, are responsible for tumor initiation and cancer progression. Most of the multi‐view data profiles contain a huge number of genes, many of which are redundant, noisy, and irrelevant. It is computationally impractical to use these massive data sets without any filtering of the feature set. High performance (deep) machine learning strategies now appear to be an essential tool to learn the hidden structure from the data. In Chapter 4, the authors have proposed a two‐step approach to systematically identify gene signatures from multi‐omics head and neck cancer data. First, an autoencoder‐based strategy is used to integrate gene expression and methylation data. From this, the features are extracted by using the information from the bottleneck layer of the autoencoder. The features represent the combined representation of the two omics profiles. Next, the features that stem from the integrated data are applied to learn another deep learning model called the capsule network. The coupling coefficients between primary and output capsules are also analysed to interpret the features captured by the capsules.

      Cancer is one of the most devastating diseases worldwide. It affects nearly every household, although cancer types are prevalent in different geographical regions. One example is breast cancer, which is the most common type of cancer in women worldwide. Therefore, prevention strategies are needed to address this issue. Identifying risk factors of breast cancer is crucial since it allows physicians to acquaint them with the risks. Accordingly, physicians can recommend precautionary actions. In the first part of Chapter 6, the authors detail the discovery of significant rules for breast cancer patients, focusing on different ethnic groups. Predicting the risk of the occurrence of breast cancer is an essential issue for clinical oncologists. A reliable prediction will help oncologists and other clinicians in their decision‐making process and allow clinicians to choose the most reliable and evidence‐based treatment. In the second part of the chapter, a super learner or stacked ensemble technique is employed to the breast cancer data set obtained from the Breast Cancer Surveillance Consortium (BCSC) database. A comparison of the performance of the super learner and the individual base learners is conducted. The results of the first part of this study (rule extraction from breast cancer patients in distinct ethnic groups) found well‐known ethnic disparities in cancer prevalence. The experimental results revealed that the produced rules hold the highest confidence level. The crucial rules, which can be easily understood, are also interpreted.

      Negative‐stain transmission electron microscopy (TEM) is considered a fundamental approach for virus detection and identification. In this context, Chapter 7 presents a new architecture, based on neuro‐rough hybridization, for the analysis of TEM images. It assumes that a specific local descriptor at a given scale may be relevant in classifying a particular pair of virus classes but may not be able to encapsulate the inherent characteristics of another pair of classes. Important features from class‐pair relevant descriptors are, therefore, first identified using the rough hypercuboid approach, and then discriminatory features are learned using the contrastive divergence algorithm of the restricted Boltzmann machine (RBM). Finally, a support vector machine (SVM) with a linear kernel is adopted to categorize the TEM images into one of the known virus classes. The proficiency of the proposed approach with respect to several state‐of‐the‐art methods was established on a publicly available, benchmark Virus data set.

      In Chapter 9, a machine learning approach is proposed to predict whether the given brain MRI scans are normal or abnormal. This prediction is needed for treatment planning and diagnosis. The proposed method makes use of the bilateral symmetric nature of the human brain by splitting it into the left and right hemispheres (LHS and RHS) to extract the feature differences between the hemispheres. A feature set of 763 x 39 dimensions are created as the input for the classification model. Among these 39 features, 16 were selected by the Pearson's correlation coefficient to have correlation value greater than 0.3. To train the model, six tumor volumes from the BraTS2013 and two normal volumes from the IBSR‐18 data sets were used. For testing the model, 11 tumor volumes from the BraTS2013 and two normal volumes from the IBSR‐18 data sets were used. The k‐nearest neighbourhood (KNN) model was trained using the training data and the prediction done on the test data. A stratified k‐fold cross‐validation was used to validate the proposed model. The proposed model was analysed in terms of false alarm (FA), missed alarm (MA), and accuracy (ACC) for performance. The results showed that the proposed model yielded a 98 and 95.6% accuracy on the validation and testing data, respectively.

      Chapter 10 draws a line of conclusion on the future aspects of healthcare informatics while stressing the need for the effective management of healthcare resources.

      This volume will benefit several categories of students and researchers. At the student level, this volume can serve as a treatise/reference book for the special papers at the master's level aimed at inspiring future researchers. Newly inducted PhD aspirants would also find the contents of this volume useful as far as their compulsory coursework is concerned. At the researchers' level, those interested in interdisciplinary research would also benefit from the volume. After all, the enriched interdisciplinary contents of the volume will always be a subject of interest to the faculties, existing research communities, and new research aspirants from diverse disciplines of the concerned departments of premier institutes across the globe.

Cooch Behar, India