Applications 16.1 Threats for DNA Nanostructures 16.2 Strategies to Protect DNA Origami Structures References
22 17 DNA Nanostructures for Cancer Diagnosis and Therapy 17.1 Introduction 17.2 DNA Nanostructure‐Based Diagnostics 17.3 DNA Nanostructure‐Based Drug Delivery 17.4 Challenges and Prospects References
23 Index
List of Tables
1 Chapter 8Table 8.1 Brief comparison of OT, MT, and AFM.
2 Chapter 12Table 12.1 Protein and DNA conjugation methods via noncovalent interaction....Table 12.2 Classification of protein‐DNA conjugation methods (covalent conj...
3 Chapter 16Table 16.1 Overview over the most common damages to nucleic acids and nucle...
List of Illustrations
1 Chapter 1Figure 1.1 History of DNA nanotechnology and DNA origami technology. Progres...Figure 1.2 DNA nanotechnology before the emergence of DNA origami. (a) DNA d...Figure 1.3 DNA origami. (a) Method to prepare a DNA origami structure from t...Figure 1.4 Programmed self‐assembly of DNA origami. (a) Structure of DNA ori...Figure 1.5 Design and construction of three‐dimensional DNA origami structur...Figure 1.6 Selective incorporation of nanoparticles, proteins, enzymes, and ...Figure 1.7 Detection of target RNA by hybridization with probe DNA strands i...Figure 1.8 (a) Schematic illustration of pinching of a target molecule.(...Figure 1.9 Direct observation of DNA structural change and enzyme reactions ...Figure 1.10 DNA‐PAINT super‐resolution imaging. (a) DNA origami tile with tw...Figure 1.11 Assembly line with a DNA walker capturing gold particles and DNA...Figure 1.12 Helical AuNP plasmonic structures constructed on a DNA origami. ...Figure 1.13 A dynamic DNA origami structure that changes the structure in re...Figure 1.14 (a) DNA origami channel structure. Tubular pores (dark gray), ma...Figure 1.15 Delivery of DNA origami structures to cells and functional contr...Figure 1.16 A DNA nanorobot that recognizes cells. Schematic drawings of the...
2 Chapter 2Figure 2.1 Pre‐origami wireframe DNA structures. (a) Nadrian Seeman’s DNA cu...Figure 2.2 Hierarchical DNA origami wireframe. (a) Schematics for the strate...Figure 2.3 Entire DNA origami design. (a) DNA origami tetrahedron based on c...Figure 2.4 Entire DNA origami design. (a) (I) BSCOR and vHelix design pipeli...Figure 2.5 DNA origami barrel‐like structure. (a) Perspective view. (b) Fron...Figure 2.6 Quantification of the movement of the internal block during the s...
3 Chapter 3Figure 3.1 DNA origami nanoscissors exhibiting open/closed switching in resp...Figure 3.2 G‐quadruplex induced large deformation of the DNA origami bending...Figure 3.3 Photoregulated DNA rotary device. (a) A bar‐shaped rotor composed...Figure 3.4 Dynamic events involved in a lipid bilayer‐assisted self‐assembly...Figure 3.5 Placing square‐shaped DNA origami into lipid bilayer‐supported 2D...Figure 3.6 Photoresponsive reversible assembly of a hexagonal DNA origami di...
4 Chapter 4Figure 4.1 Schematic design process of nucleic acid structures with a simple...Figure 4.2 Software for visualizing macromolecules. (a) Typical screenshot o...Figure 4.3 The result of molecular dynamic simulation of DNA tile. Six repre...Figure 4.4 Snapshot of NAMOT software. A DNA cube structure is visualized us...Figure 4.5 Software for abstract design of DNA nanostructure. Snapshots of (...Figure 4.6 Snapshots of SARSE software designing a dolphin‐shaped DNA origam...Figure 4.7 Snapshots of caDNAno software. (a) The new version of caDNAno tha...Figure 4.8 Software dedicated to the design of wireframe DNA origami structu...Figure 4.9 Snapshots of the simulation results of a DNA origami smiley face ...
5 Chapter 5Figure 5.1 DNA properties and capabilities.Figure 5.2 DNA rupture modes: (a) shearing mode, where forces are applied at...Figure 5.3 DNA in force spectroscopy. (a) DNA‐origami molecular force clamp...Figure 5.4 DNA devices that control biomolecular interactions. (a) DNA nanov...Figure 5.5 DNA frames, Tweezers, and calipers to probe biomolecular interact...Figure 5.6 DNA machines to probe biomolecular interactions. (a) Wireframe DN...Figure 5.7 DNA devices to study biological motors. (a) Disengagement of one ...Figure 5.8 DNA walkers. (I) A plasmonic nanorod that walks on a DNA origami ...Figure 5.9 DNA computing. (a) Molecular logic gates on DNA origami for micro...
6 Chapter 6Figure 6.1 (a) Excitation of the LSPR in a spherical AuNP. The incident lase...Figure 6.2 Summary of the advantages and disadvantages of the three nanopart...Figure 6.3 (a). Schematic representation of the self‐assembly process of pla...Figure 6.4 (a) Design of the DNA origami chiral plasmonic sensor and the ope...Figure 6.5 Formation of AuNP dimers using a triangular DNA