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The Emperor of all Maladies A BIOGRAPHY OF CANCER SIDDHARTHA MUKHERJEE Fourth Estate An imprint of HarperCollinsPublishers Ltd. 1 London Bridge Street London SE1 9GF Copyright © Siddhartha Mukherjee 2011 The right of Siddhartha Mukherjee to be identified as the author of this work has been asserted by him in accordance with the Copyright, Designs and Patents Act 1988 A catalogue record for this book is available from the British Library All rights reserved under International and Pan-American Copyright Conventions. By payment of the required fees, you have been granted the non-exclusive, non-transferable right to access and read the text of this ebook on-screen. No part of this text may be reproduced, transmitted, down-loaded, decompiled, reverse engineered, or stored in or introduced into any information storage and retrieval system, in any form or by any means, whether electronic or mechanical, now known or hereinafter invented, without the express written permission of HarperCollins ebooks HarperCollinsPublishers has made every reasonable effort to ensure that any picture content and written content in this ebook has been included or removed in accordance with the contractual and technological constraints in operation at the time of publication Source ISBN: 9780007250912 Ebook Edition © FEBRUARY 2011 ISBN: 9780007435814 Version: 2017-09-20 To ROBERT SANDLER (1945–1948), and to those who came before and after him. Illness is the night-side of life, a more onerous citizenship. Everyone who is born holds dual citizenship, in the kingdom of the well and in the kingdom of the sick. Although we all prefer to use only the good passport, sooner or later each of us is obliged, at least for a spell, to identify ourselves as citizens of that other place. —Susan Sontag1 Contents
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Prologue Part One - “Of blacke cholor, without boyling” “A suppuration of blood” “A monster more insatiable than the guillotine” Farber’s Gauntlet A Private Plague Onkos Vanishing Humors “Remote Sympathy” A Radical Idea The Hard Tube and the Weak Light Dyeing and Dying Poisoning the Atmosphere The Goodness of Show Business The House That Jimmy Built Part Two - An Impatient War “They form a society” “These new friends of chemotherapy” “The butcher shop” An Early Victory Mice and Men VAMP An Anatomist’s Tumor An Army on the March The Cart and the Horse “A moon shot for cancer” Part Three - “Will you turn me out if I can’t get better?” “In God we trust. All others [must] have data” “The smiling oncologist” Knowing the Enemy Halsted’s Ashes Counting Cancer Part Four - Prevention Is the Cure “Coffins of black” The Emperor’s Nylon Stockings “A thief in the night” “A statement of warning” Photographic Insert “Curiouser and curiouser” “A spider’s web” STAMP The Map and the Parachute Part Five - “A Distorted Version of Our Normal Selves” “A unitary cause” Under the Lamps of Viruses “The hunting of the sarc” The Wind in the Trees A Risky Prediction The Hallmarks of Cancer Part Six - The Fruits of Long Endeavors “No one had labored in vain” New Drugs for Old Cancers A City of Strings Drugs, Bodies, and Proof A Four-Minute Mile The Red Queen’s Race Thirteen Mountains Atossa’s War Notes Glossary Selected Bibliography Index Acknowledgments Author’s Note In 2010, about six hundred thousand Americans, and more than 7 million humans around the world, will die of cancer. In the United States, one in three women and one in two men will develop cancer during their lifetime. A quarter of all American deaths, and about 15 percent of all deaths worldwide, will be attributed to cancer. In some nations, cancer will surpass heart disease to
