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Table of Contents
1 Cover
2 Preface
8 1 Introduction Receptors Transport systems Enzymes Second messengers G‐proteins
9 2 Drug–receptor interactions Binding of drugs to receptors Antagonists Receptor reserve Partial agonists Intrinsic efficacy Bioassay Binding assays Localization of receptors Tachyphylaxis, desensitization, tolerance and drug resistance
10 3 Drug absorption, distribution and excretion Routes of administration Distribution and excretion Excretion
11 4 Drug metabolism Drugs Liver Phase I reactions Phase II reactions Factors affecting drug metabolism Metabolism and drug toxicity
12 5 Local anaesthetics Na+ channels Action potential Mechanism of local anaesthetics Chemistry Unwanted effects Methods of administration
13 6 Drugs acting at the neuromuscular junction Presynaptic agents Competitive neuromuscular blocking drugs Depolarizing neuromuscular blocking drugs
14 7 Autonomic nervous system Effects of sympathetic stimulation Acetylcholine
15 8 Autonomic drugs acting at cholinergic synapses Cholinomimetics Muscarinic antagonists (antimuscarinics)
16 9 Drugs acting on the sympathetic system Sympathomimetics Adrenoceptor antagonists
17 10 Ocular pharmacology Glaucoma Mydriatics
18 11 Asthma, hay fever and anaphylaxis Mediators Bronchodilators Cromoglicate Corticosteroids Acute severe asthma Antihistamines
19 12 Drugs acting on the gastrointestinal tract I Acid secretion Protective factors Ulcer healing drugs Antacids
20 13 Drugs acting on the gastrointestinal tract II Motility stimulants Laxatives Antidiarrhoeal