Reproduced with permission of Justin Hobson, https://commons.wikimedia.org/wiki/File:F5_tornado_Elie_Manitoba_2007.jpg.
Respiration might seem intuitively biological, but fires, in a rudimentary way, “respire” organic material. They burn organic carbon in oxygen to produce waste products: carbon dioxide and water. The chemical reaction involved in this process is identical to aerobic respiration used to produce energy in some types of life; the only difference is that the reaction is biochemically controlled in life and uncontrolled in fires (Figure 2.7).
Figure 2.7 A wildfire burns organic carbon in oxygen to produce carbon dioxide and water in an identical chemical reaction performed by respiring animals.
Sensitivity is a highly equivocal term. What do we mean by this? If we mean response to external stimuli, then many abiotic systems are sensitive to changes in the natural environment around them, tornados providing yet another example of a complex system that is sensitive to changing weather and climatic perturbations.
Growth is not unique to life. Salt crystals, when exposed to the appropriate conditions, such as a saturated salt solution, can grow (Figure 2.8).
Figure 2.8 Life grows, but crystals do as well. These salt (NaCl) crystals can grow if they are placed in a saturated salt solution.
Source: Reproduced with permission of Mark Schellhase, https://commons.wikimedia.org/wiki/User:Mschel#/media/File:Salt_Crystals.JPG.
Reproduction is a more obviously biological trait. However, molecules made in the laboratory, such as ribonucleic acid (RNA) molecules, can reproduce, but most people would not describe them as alive. Excretion too is an equivocal term since chemical reactions produce products, wastes if you like, that are “excreted” from chemical systems. Nutrition is the uptake of reactants that can be viewed in purely chemical terms.
Evolution, considered broadly, need not necessarily be uniquely biological. Even computer programs can be made to evolve in a rudimentary sense – their outputs are selected by a defined numerical environment and used to generate the next set of outputs, changing in response to their digital environment. Although in this case, the “evolution” is overseen by advanced creatures who themselves are a product of evolution. Some people might say that such computers and their programs are biosignatures. Even if we were to create androids that exhibit all the characteristics of life, they would still be made by human beings, who are the products of Darwinian evolution, making even the most advanced self-aware android a biosignature and not a living thing in its own right.
Human beings themselves, through their capacity to genetically remove diseases from the human genome and their increasing attempts to control the onslaught of the microbial world, are putting themselves outside many of the factors that once selected them in a Darwinian sense. Does that mean as we weaken the grip of Darwinian evolution, we are putting ourselves outside the definition of life? I suspect we would think that these technologies have little bearing on whether we are alive.
Many of these characteristics are incorporated into attempts to define life. The first part of Joyce's definition that life is a “self-sustained chemical system” recognizes the characteristic of respiration, excretion, and nutrition, and the second part – “capable of undergoing Darwinian evolution” – recognizes its evolutionary capacity.
In addition to finding non-biological examples of each of life's characteristics, we can find entities made of the molecules that we associate with living things, but which fail to exhibit characteristics that we associate with most life. For example, viruses contain nucleic acids and proteins, the molecules of life, so why would they be excluded from the category of living things? One reason is that viruses, such as influenza viruses, are particles that require a host to replicate, taking over cell machinery to reproduce themselves (Figure 2.9). As they cannot reproduce on their own, they lack the characteristic of reproduction, often considered to be a defining characteristic of life. Many people prefer to call them “biological particles” or some such word or phrase that captures the idea that they are made up of molecules associated with life, but are not life.
Figure 2.9 Viruses as biological entities. A virus cannot reproduce on its own. It requires a cell within which to replicate. This is exemplified by these Rubella virus particles (center) budding from host cell tissue (lower left and upper right) and visualized as stained material using a transmission electron microscope. Some people consider that this places viruses outside a definition of life.
Source: Reproduced with permission of Dr. Fred Murphy and Sylvia Whitfield, https://commons.wikimedia.org/wiki/File:Rubella_virus_10221_lores.jpg.
The problem with excluding viruses is that the same argument can easily be applied to other organisms that we do think are alive. What about a rabbit? Like a virus, it cannot replicate on its own. It requires another rabbit. Is a rabbit on its own dead, but only a living thing when it has found a mate? What about you? You cannot reproduce on your own. If you are single, does that make you dead? I think you'd disagree. Another example would be sterile animals, such as a mule (Figure 2.10), which cannot reproduce even if they do find a mate. Very quickly we arrive at a reductio ad absurdum and the discussion goes nowhere.
Figure 2.10 A mule is a sterile creature, which means that it cannot reproduce. If that puts it outside a definition of life that includes reproduction as a defining characteristic of life, does that mean that a mule is not life?
Source: Reproduced with permission of Sogospelman, https://commons.wikimedia.org/wiki/File:Mule_(1).jpg.
These types of deliberations can be applied to many of the other characteristics of living entities. Even with respect to evolution, we might find exceptions. If we were to show that a deep subsurface microbe did not evolve, but rather remained as an isolated population in a pocket of rock underground with no selection pressure to evolve over million-year timescales, would we therefore say that these organisms were not alive? Clearly, evolution is necessary for life to emerge on a planet or to produce a biosphere containing diverse species, but once that evolutionary experiment is underway, we could conceive of organisms that evolved very little or not at all over given periods of time.
These considerations suggest that we can find characteristics that are broadly useful for defining the sorts of entities we might consider as “life,” but that they do not provide an unambiguous description of living things.
2.5 Schrödinger and Life
Physicist Erwin Schrödinger (1887–1961; Figure 2.11) famously attempted to describe life in his seminal book, What is Life?, published in 1944 following a series of lectures given at Trinity College, Dublin, in 1943. Quite apart from some fascinating predictions about the nature of genetic material (that it was an “aperiodic” crystal – a crystal that lacks long-range order – for which he attempted to estimate the size), he also attempted to get at the nature of life.
Figure 2.11 Erwin Schrödinger. He attempted to understand life from a physical perspective.
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