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Biologics, Biosimilars, and Biobetters
An Introduction for Pharmacists, Physicians, and Other Health Practitioners
Edited by
Iqbal Ramzan
Sydney Pharmacy School, Faculty of Medicine and Health
The University of Sydney
Sydney, New South Wales, Australia
This edition first published 2021
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Library of Congress Cataloging‐in‐Publication Data Applied for:
ISBN: 9781119564652
Cover Design: Wiley
Cover Image: Courtesy of David Hibbs. Image based on Protein Database ID (PDBID): 1IGY – Structure of Immunoglobulin, organism Mus musculus (Harris, et al. (1998); Crystallographic structure of an intact IgG1 monoclonal antibody at J. Mol. Biol. 275: 861–872), created with the Maestro program (Schrödinger LLC). Natural outdoors bokeh background in green and blue tones with sun rays © guvendemir/Getty Images
List of Contributors
Jeffry Adiwidjaja Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Esteban Cruz Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Hans C. Ebbers Scientific Affairs Biosimilars Biogen International GmbH Baar Switzerland
Paul W. Groundwater Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Jane R. Hanrahan Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Bryson A. Hawkins Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
David E. Hibbs Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Kevin Huang Department of Medicine Harvard Medical School Boston MA USA
Prateek Jain Independent consultant Toronto, Canada
Reza Kahlaee Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Veysel Kayser Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Felcia Lai Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Christine Y. Lu Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA
Hemant Malhotra Department of Medical Oncology Sri Ram Cancer Center Mahatma Gandhi Medical College Hospital Jaipur India
Andrew J. McLachlan Sydney Pharmacy School Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia
Cody Midlam Willis Towers Watson Cincinnati OH USA
Sanja Mirkov School of Pharmacy The University of Auckland Auckland New Zealand Ramsay Pharmacy Services Melbourne Victoria Australia
Catherine