10.2 DFT Modeling of Transition Metal‐Catalyzed Fluorination Reactions 10.2.1 Ti‐Catalyzed Fluorination Reaction 10.2.2 Mn‐Catalyzed Fluorination Reactions 10.2.3 Fe‐Catalyzed Fluorination Reactions 10.2.4 Rh‐Catalyzed Fluorination Reactions 10.2.5 Ir‐Catalyzed Fluorination Reactions 10.2.6 Pd‐Catalyzed Fluorination Reactions 10.2.6.1 Pd‐Catalyzed Nucleophilic Fluorination 10.2.6.2 Pd‐Catalyzed Electrophilic Fluorination 10.2.7 Cu‐Catalyzed Fluorination Reactions 10.2.7.1 Cu‐Catalyzed Nucleophilic Fluorination 10.2.7.2 Cu‐Mediated Radical Fluorination 10.2.8 Ag‐Catalyzed Fluorination Reactions 10.2.9 Zn‐Catalyzed Fluorination Reactions 10.3 DFT Modeling of Organocatalytic Fluorination Reactions 10.3.1 Fluorination Reactions Catalyzed by Chiral Amines 10.3.1.1 Chiral Secondary Amines‐Catalyzed Fluorination Reactions 10.3.1.2 Chiral Primary Amines‐Catalyzed Fluorination Reactions 10.3.2 Tridentate Bis‐Urea Catalyzed Fluorination Reactions 10.3.3 Hypervalent Iodine‐Catalyzed Fluorination Reactions 10.3.4 N‐Heterocyclic Carbene‐Catalyzed Fluorination Reactions 10.4 DFT Modeling of Enzymatic Fluorination Reaction 10.5 Conclusions Acknowledgments References
15 11 Current Trends in the Design of Fluorine‐Containing Agrochemicals 11.1 Introduction 11.2 Role of Fluorine in the Design of Modern Agrochemicals 11.3 Fluorinated Modern Agrochemicals 11.3.1 Herbicides Containing Fluorine 11.3.1.1 Acetohydroxyacid Synthase/Acetolactate Synthase Inhibitors 11.3.1.2 Protoporphyrinogen Oxidase Inhibitors 11.3.1.3 Cellulose Biosynthesis Inhibitors 11.3.1.4 Very Long‐Chain Fatty Acid Synthesis Inhibitors 11.3.1.5 Auxin Herbicides 11.3.1.6 Hydroxyphenylpyruvate Dioxygenase Inhibitors 11.3.1.7 Selected Fluorine‐Containing Herbicide Development Candidates 11.3.2 Fungicides Containing Fluorine 11.3.2.1 Fungicidal Succinate Dehydrogenase Inhibitors 11.3.2.2 Complex III Inhibitors 11.3.2.3 Sterolbiosynthesis (Sterol‐C14‐Demethylase) Inhibitors 11.3.2.4 Polyketide Synthase Inhibitors 11.3.2.5 Oxysterol‐Binding Protein Inhibitors 11.3.2.6 Selected Fluorine‐Containing Fungicide Development Candidates 11.3.3 Insecticides Containing Fluorine 11.3.3.1 Nicotinic Acetylcholine Receptor Competitive Modulators 11.3.3.2 Ryanodine Receptor (RyR) Modulators 11.3.3.3 GABA‐Gated CI‐Channel Allosteric Modulators 11.3.3.4 Selected Fluorine‐Containing Insecticide Development Candidates 11.3.4 Acaricides Containing Fluorine 11.3.4.1 Mitochondrial Complex II Electron Transport Inhibitors 11.3.4.2 Selected Fluorine‐Containing Acaricide Development Candidates 11.3.5 Nematicides Containing Fluorine 11.3.5.1 Nematicides with Unknown Biochemical MoA 11.3.5.2 Nematicidal Succinate Dehydrogenase Inhibitors 11.3.5.3 Selected Fluorine‐Containing Nematicide Development Candidates 11.4 Summary and Prospects References
16 12 Precision Radiochemistry for Fluorine‐18 Labeling of PET Tracers 12.1 Introduction 12.2 Electrophilic 18F‐Fluorination with [18F]F2 and [18F]F2‐Derived Reagents 12.3 Nucleophilic Aliphatic 18F‐Fluorination 12.3.1 Transition Metal‐Free Nucleophilic Aliphatic Substitution with [18F]Fluoride 12.3.2 Transition Metal‐Mediated Aliphatic 18F‐Fluorination 12.4 Nucleophilic Aromatic 18F‐Fluorination with [18F]Fluoride 12.4.1 Transition Metal‐Free Nucleophilic Aromatic 18F‐Fluorination with [18F]Fluoride 12.4.2 Transition Metal‐Mediated Aromatic 18F‐Fluorination 12.5 18F‐Labeling of Multifluoromethyl Motifs with [18F]Fluoride 12.6 Summary and Conclusions References
17 Index