William Gregory

Cobert's Manual Of Drug Safety And Pharmacovigilance (Third Edition)


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Vaccine Adverse Event Reporting

       European Union System

       Sources of Additional Information

       Chapter 42Business Partners and Exchange of Safety Data

       Introduction

       Why a Written Safety Exchange Agreement is Needed

       Telling the Safety Department about a New Contract or Arrangement

       The Generic, Boilerplate, or Template Agreement

       Developing a Safety Agreement with the Safety Department

       Pharmacovigilance Agreement Database

       Safety Agreement Contents

       Regulatory Status

       Regulatory Responsibilities

       Regulatory Documents

       Health Authority Queries and Requests

       Regulatory Submissions

       Investigator and Investigational Review Board/Ethics Committee Notifications: Blinding and Unblinding, Data Monitoring Committees (DMCs/DMSBs/DMSCs), Data Safety Boards

       Safety Databases

       Definitions

       Data and Mechanisms of Data Exchange

       Signaling, Safety Reviews, and Risk Management

       Audits

       Other Issues

       Soft Points

       Comments

       Drug Due Diligence

       Chapter 43Data Privacy and Security

       Introduction

       United States Health Insurance Portability and Accountability Act (HIPAA)

       The European Union and the Privacy Regulation & Directive

       EU-US Privacy Shield

       Frequently Asked Question

       Chapter 44The Roles and Interactions of Companies, Governments, Non-governmental Organizations, and Others in the World of Pharmacovigilance

       Introduction

       Pharmaceutical Companies

       Governments

       Media

       NGOs and Lobbies

       Industry Organizations

       Litigation, Lawyers, and Legalities

       Other Groups

       Organizations for Drug Safety Personnel

       Conclusion and Comments

       Frequently Asked Question

       Chapter 45Real-World Issues: Case Studies

       Fialuridine

       Fen–Phen

       Nomifensine

       TGN-1412/TAB08

       Chapter 46Medical Marijuana and Pharmacovigilance

       Overview and Pharmacology

       US Federal Regulatory Situation

       US State Regulatory Situation

       Efficacy