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Understanding Platelet-Rich Fibrin
Library of Congress Cataloging-in-Publication Data
Names: Miron, Richard J. (Richard John), 1983- editor.
Title: Understanding platelet-rich fibrin / edited by Richard J. Miron.
Description: Batavia, IL : Quintessence Publishing Co Inc, [2021] | Includes bibliographical references and index. | Summary: "This book outlines the science behind platelet-rich fibrin and then details how to use it in clinical practice to optimize healing outcomes and promote tissue regeneration. Applications include gingival recessions, intrabony and furcation defects, extraction site management, implant dentistry, guided bone regeneration, sinus grafting, oral and maxillofacial surgery, regenerative endodontics, facial esthetics, and medicine"--Provided by publisher.
Identifiers: LCCN 2020035734 | ISBN 9781647240493 (hardcover)
Subjects: MESH: Platelet-Rich Fibrin | Fibrin--therapeutic use | Tissue Engineering | Bone Regeneration
Classification: LCC QP91 | NLM WH 400 | DDC 612.1/15--dc23
LC record available at https://lccn.loc.gov/2020035734
©2021 Quintessence Publishing Co, Inc
Quintessence Publishing Co, Inc
411 N Raddant Road
Batavia, IL 60510
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All rights reserved. This book or any part thereof may not be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, or otherwise, without prior written permission of the publisher.
Editor: Leah Huffman
Design: Sue Zubek
Production: Angelina Schmelter
Printed in the USA
Contents
1Evolution of Platelet Concentrates
2Biology of PRF: Fibrin Matrix, Growth Factor Release, and Cellular Activity
3Horizontal Versus Fixed-Angle Centrifugation of PRF: Optimization of C-PRF
4Understanding Relative Centrifugal Force (G-Force)
5Protocols for PRF
6Importance of Centrifugation Tubes for the Production of PRF
7Biologic Characterization of e-PRF Membranes
8Armamentarium in a PRF Kit
9Phlebotomy
10Fabricating Various PRF Modalities
11Overview of Clinical Indications Using PRF
12Use of PRF for the Treatment of Gingival Recessions
13Use of PRF for the Treatment of Intrabony and Furcation Defects
14Use of PRF for Extraction Site Management
SECTION III | IMPLANT DENTISTRY
15Use of PRF as an Adjunct Therapy to Implant Dentistry
16Use of PRF in Guided Bone Regeneration
17Use of PRF for Sinus Grafting
SECTION IV | ADDITIONAL DENTAL AND MEDICAL APPLICATIONS
18Use of PRF in Oral and Maxillofacial Surgery
19Use of PRF in Regenerative Endodontics
20Use of PRF in Facial Esthetics
21Medical Uses of PRF
22Future Research with PRF
Index
I would like to dedicate this textbook specifically to Dr Fatiha Chandad and the Dental Faculty at the University of Laval in Quebec, Canada, who devoted countless hours to training students like me in dentistry.
Dr Chandad, Dean of Dental Research, was someone who motivated me and more importantly made it possible for students to work within her laboratory on research projects during their 4 years of dental studies. It was here that I first started my research activities on PRP/PRF and became fascinated with research as a whole. Dr Chandad is one of the only people I have ever met never wanting to be recognized for her achievements, instead insisting that her students be recognized and at the forefront of their own success. It was during these times that I was awarded the prestigious Hatton Award in Canada and was later named the IADR Young Investigator of the Year in Implant Dentistry.
In appreciation of her contributions to my career, 100% of the royalties from this textbook will be donated to create a scholarship named after her for new dental graduates at the University of Laval. Milles fois merci pour tout tes efforts!
Many important medical/dental discoveries were stumbled upon by pure chance. An example of this is osseointegration, which launched the modern era of dental implants and orthopedic-embedded prostheses. It occurred when orthopedic researcher Per-Ingvar Brånemark found that his titanium research cages in sheep were so completely ingrown with bone that he couldn’t remove them. Similarly, platelet-rich plasma (PRP)/platelet-rich fibrin (PRF) was discovered by the serendipity of observing accelerated and more complete healing in patients who developed hematomas. From that simple observation in the 1980s, the components of the blood clot responsible for the advanced healing have since been determined to be the complete and active growth factors in the alpha granules of viable platelets