the same as described for the Haemonetics systems and for whole blood collection. In these systems, blood is withdrawn from the donor into a closed, disposable plastic set with a total extracorporeal volume of about 165 mL. Blood separation occurs in a small, 7‐mL (Auto C or Aurora) or 15‐mL (Aurora Xi) cylinder that is part of the system. A magnet causes rotation of the cylinder inside a larger compartment. The cylinder is composed of a membrane, and as the cylinder rotates, plasma moves peripherally through the membrane, thus providing the filtration part of the separation system. The system does not operate in a continuous‐flow manner; blood is returned intermittently to the donor through the single venipuncture and the process is repeated. The Auto‐C system collects about 500 mL of plasma in about 30 minutes [129, 130]. The Aurora Xi is slightly more efficient; however, both systems are used extensively for the production of source plasma for further manufacture of plasma derivatives.
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