href="#ulink_da98a735-bb54-5dfc-aa20-49b787ea23f5">163. Pajvani UB, Du X, Combs TP, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity. J Biol Chem 2003;278:9073–9085.
164. Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999;100:2473–2476.
165. Dunmore SJ, Brown JEP. The role of adipokines in β-cell failure of type 2 diabetes. J Endocrinol 2013;216:T37–T45.
166. Marseglia L, Manti S, D’Angelo G, et al. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci 2014;16:378–400.
167. Nokhbehsaim M, Eick S, Nogueira AV, et al. Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells. Mediators Inflamm 2013;2013:437123.
168. Tüter G, Kurtiş B, Serdar M, et al. Effects of phase I periodontal treatment on gingival crevicular fluid levels of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1. J Clin Periodontol 2005;32:1011–1015.
169. Arakaki PA, Marques MR, Santos MCLG. MMP-1 polymorphism and its relationship to pathological processes. J Biosci 2009;34:313–320.
170. Zhao J. Interplay among nitric oxide and reactive oxygen species: a complex network determining cell survival or death. Plant Signal Behav 2007;2:544–547.
171. Griendling KK, Touyz RM, Zweier JL. Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American Heart Association. Circulation Res 2016;119:e39–e75.
172. Filippo C, Verza M, Coppola L, Rossi F, D’Amico M, Marfella R. Insulin resistance and postprandial hyperglycemia the bad companions in natural history of diabetes: effects on health of vascular tree. Curr Diabetes Rev 2007;3:268–273.
173. D’Aiuto F, Nibali L, Parkar M, Patel K, Suvan J, Donos N. Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res 2010;89:1241–1246.
174. Herrera BS, Martins-Porto R, Campi P, et al. Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats. Arch Oral Biol 2011;56:41–47.
175. Herrera BS, Martins-Porto R, Maia-Dantas A, et al. INOS-derived nitric oxide stimulates osteoclast activity and alveolar bone loss in ligature-induced periodontitis in rats. J Periodontol 2011;82:1608–1615.
176. Lavrovsky Y, Chatterjee B, Clark RA, Roy AK. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol 2000;35: 521–532.
177. Allen EM, Matthews JB, O’Halloran DJ, Griffiths HR, Chapple IL. Oxidative and inflammatory status in type 2 diabetes patients with periodontitis. J Clin Periodontol 2011;38:894–901.
178. Roberts HM, Grant MM, Hubber N, Super P, Singhal R, Chapple ILC. Impact of bariatric surgical intervention on peripheral blood neutrophil (PBN) function in obesity. Obes Surg 2018;28:1611–1621.
179. Atabay VE, Lutfioğlu M, Avci B, Sakallioglu EE, Aydoğdu A. Obesity and oxidative stress in patients with different periodontal status: a case-control study. J Periodontal Res 2017;52:51–60.
180. Pacher P, Beckman J, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007;87:315–424.
181. Campi P, Herrera BS, de Jesus FN, et al. Endothelial dysfunction in rats with ligature-induced periodontitis: participation of nitric oxide and cycloxygenase-2-derived products. Arch Oral Biol 2016;63:66–74.
182. Assmann TS, Brondani LA, Bouças AP, et al. Nitric oxide levels in patients with diabetes mellitus: a systematic review and meta-analysis. Nitric Oxide 2016;61:1–9.
183. Daffu G, del Pozo CH, O’Shea KM, Ananthakrishnan R, Ramasamy R, Schmidt AM. Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond. Int J Mol Sci 20131;14:19891–19910.
184. Luevano-Contreras C, Chapman-Novakofski K. Dietary advanced glycation end products and aging. Nutrients 2010;2:1247–1265
185. Ramasamy R, Yan SF, Schmidt AM. Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci 2011; 1243:88–102.
186. Kirstein M, Brett J, Radoff S, Ogawa S, Stern D, Vlassara H. Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging. Proc Natl Acad Sci U S A 1990;87: 9010–9014.
187. Cipollone F, Iezzi A, Fazia M, et al. The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control. Circulation 2003;108:1070–1017.
188. Schleicher ED, Wagner E, Nerlich AG. Increased accumulation of the glycoxidation product N(ε)- (carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 1997;99:457–468.
189. Schmidt AM, Yan S Du, Wautier JL, Stern D. Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res 1999;84:489–497.
190. Chang PC, Chien LY, Yeo JF, et al. Progression of periodontal destruction and the roles of advanced glycation end products in experimental diabetes. J Periodontol 2013;84:379–388.
191. Lin SJ, Tu YK, Tsai SC, Lai SM, Lu HK. Non-surgical periodontal therapy with and without subgingival minocycline administration in patients with poorly controlled type II diabetes: a randomized controlled clinical trial. Clin Oral Investig 2012;16:599–609.