CV, Carrera-Silva EA, Bosurgi L, Ghosh S: TAM receptor signaling in immune homeostasis. Annu Rev Immunol 2015;33:355–391.
86Qin B, Wang J, Ma N, Yang M, Fu H, Liang Y, Huang F, Yang Z, Zhong R: The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjogren’s syndrome. Joint Bone Spine 2015;82:258–263.
87Zheng S, Hedl M, Abraham C: TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages. J Immunol 2015;194:1928–1937.
88Wang X, Malawista A, Qian F, Ramsey C, Allore HG, Montgomery RR: Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes. Oncotarget 2018;9:9572–9580.
89Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, Cohen PL, Earp HS, Matsushima GK: Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 2001;411:207–211.
90Seitz HM, Camenisch TD, Lemke G, Earp HS, Matsushima GK: Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol 2007;178:5635–5642.
91Wong CK, Smith CA, Sakamoto K, Kaminski N, Koff JL, Goldstein DR: Aging impairs alveolar macrophage phagocytosis and increases influenza-induced mortality in mice. J Immunol 2017;199:1060–1068.
92Cuervo AM, Wong E: Chaperone-mediated autophagy: roles in disease and aging. Cell Res 2014;24:92–104.
93Metcalf TU, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, Hiscott JB, Diamond MS, Wertheimer AM, Nikolich-Zugich J, Haddad EK: Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell 2015;14:421–432.
94Rizza W, Veronese N, Fontana L: What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Res Rev 2014;13:38–45.
95Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E: Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metab 2017;26:547–557 e548.
96Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA: A ketogenic diet extends longevity and healthspan in adult mice. Cell Metab 2017;26:539–546 e535.
97Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD: Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med 2017;9:eaai8700.
98Jiang W, Zhu Z, Thompson HJ: Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res 2008;68:5492–5499.
99Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM: mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 2010;468:1100–1104.
100Darcy J, McFadden S, Bartke A: Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations. Adipocyte 2017;6:69–75.
101Riera CE, Dillin A: Tipping the metabolic scales towards increased longevity in mammals. Nat Cell Biol 2015;17:196–203.
102Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D’Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD: The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 2015;21:263–269.
103Edwards C, Canfield J, Copes N, Rehan M, Lipps D, Bradshaw PC: D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging (Albany, NY) 2014;6:621–644.
104Pearce EL, Pearce EJ: Metabolic pathways in immune cell activation and quiescence. Immunity 2013;38:633–643.
105O’Neill LA, Pearce EJ: Immunometabolism governs dendritic cell and macrophage function. J Exp Med 2016;213:15–23.
106Camell C, Goldberg E, Dixit VD: Regulation of Nlrp3 inflammasome by dietary metabolites. Semin Immunol 2015;27:334–342.
107Serhan CN: Pro-resolving lipid mediators are leads for resolution physiology. Nature 2014;510:92–101.
108Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CN: Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. J Immunol 2014;193:4235–4244.
109Cai B, Kasikara C, Doran AC, Ramakrishnan R, Birge RB, Tabas I: MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity. Sci Signal 2018;11:eaar3721.
Ruth R. Montgomery, PhD
Department of Internal Medicine, Yale University School of Medicine
300 Cedar Street/TAC S413
New Haven, CT 06520-8031 (USA)
E-Mail [email protected]
Immunosenescence and Other Risk Factors Affecting Vaccination Success in Old Age
Weinberger B (ed): Vaccines for Older Adults: Current Practices and Future Opportunities. Interdiscip Top Gerontol Geriatr. Basel, Karger, 2020, vol 43, pp 18–35 (DOI:10.1159/000504493)
______________________
Natural Killer Cells, Aging, and Vaccination
Jacek M. Witkowskia Anis Larbib, c Aurélie Le Paged Tamàs Fülöpd
aDepartment of Pathophysiology, Medical University of Gdansk, Gdansk, Poland; bSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Singapore, Singapore; cDepartment