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Haematology
From the Image to the Diagnosis
Mike Leach MB ChB, FRCP, FRCPath
Consultant Haematologist and Honorary Senior Lecturer Haematology Laboratories and West of Scotland Cancer Centre Gartnavel General Hospital, Glasgow, UK
Barbara J. Bain MB BS, FRACP, FRCPath
Professor of Diagnostic Haematology St Mary’s Hospital Campus, Imperial College London and Honorary Consultant Haematologist St Mary’s Hospital, London, UK
There is always more to learn – the study of haematology is a constant journey, not a destination
This edition first published 2022
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Library of Congress Cataloging‐in‐Publication Data
Names: Leach, Richard M. (Haematologist), author. | Bain, Barbara J., author.
Title: Haematology : from the image to the diagnosis / Mike Leach, Barbara J. Bain.
Description: Hoboken, NJ : Wiley‐Blackwell, 2022. | Includes bibliographical references and index.
Identifiers: LCCN 2021010953 (print) | LCCN 2021010954 (ebook) | ISBN 9781119777502 (hardback) | ISBN 9781119777519 (adobe pdf) | ISBN 9781119777526 (epub)
Subjects: MESH: Hematologic Diseases–diagnosis | Blood Physiological Phenomena | Examination Questions | Case Reports
Classification: LCC RC636 (print) | LCC RC636 (ebook) | NLM WH 18.2 | DDC 616.1/5–dc23
LC record available at https://lccn.loc.gov/2021010953 LC ebook record available at https://lccn.loc.gov/2021010954
Cover Design: Wiley
Cover Image: © Mike Leach
Preface
Despite the tremendous advances that have occurred in diagnostic haematopathology in recent decades, haematology remains firmly based on a clinical assessment of the patient, on basic laboratory tests and on a critical assessment of peripheral blood and bone marrow films. In this book we seek to show how an appreciation of blood and bone marrow morphology, assessed with knowledge of the clinical context, can lead to a provisional or, sometimes, a definitive diagnosis that guides further investigation and management. Each of the 101 themes is followed by a related multiple choice question with the preferred answers and further discussion being found in the second part of the book. The multiple choice questions can have more than one true answer. The themes are sometimes single cases and sometimes a composite of related cases. The book is directed at consultants and trainees in haematology and haematopathology and at clinical and biomedical scientists in these disciplines. We hope that readers will share our enjoyment of the constant sense of discovery that accompanies haematological morphology.
All magnifications are stated in terms of the objective used. Common abbreviations that may be used without definition are given on page xi. Other abbreviations are defined on first use in a theme. All images are of films stained with a May–Grünwald–Giemsa stain unless stated otherwise. The cases are not arranged thematically, since a more random arrangement better approximates to real life.
We wish to thank our clinical and laboratory colleagues with whom we have collaborated over many years.
Mike Leach and Barbara Bain, January 2021
Abbreviations
Full blood count (FBC) components
WBCwhite blood cell countRBCred blood cell countHbhaemoglobin concentrationHcthaematocritMCVmean cell volumeMCHmean cell