Li, R., Kang, W., and Hao, X.K. (2016). Exosomal microRNA-141 is upregulated in the serum of prostate cancer patients. Onco. Targets Ther. 9: 139–148.
65 Lobb, R.J., Becker, M., Wen, S.W., Wong, C.S., Wiegmans, A.P., Leimgruber, A., and Moller, A. (2015). Optimized exosome isolation protocol for cell culture supernatant and human plasma. J. Extracell Vesicles 4: 27031.
66 Logozzi, M., De Milito, A., Lugini, L., Borghi, M., Calabro, L., Spada, M., Perdicchio, M., Marino, M.L., Federici, C., Iessi, E., Brambilla, D., Venturi, G., Lozupone, F., Santinami, M., Huber, V., Maio, M., Rivoltini, L., and Fais, S. (2009). High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS One 4: e5219.
67 Lu, Q., Zhang, J., Allison, R., Gay, H., Yang, W.X., Bhowmick, N.A., Frelix, G., Shappell, S., and Chen, Y.H. (2009). Identification of extracellular delta-catenin accumulation for prostate cancer detection. Prostate 69: 411–418.
68 Macfarlane, L.A. and Murphy, P.R. (2010). MicroRNA: Biogenesis, function and role in cancer. Curr. Genom. 11: 537–561.
69 Madhavan, B., Yue, S., Galli, U., Rana, S., Gross, W., Muller, M., Giese, N.A., Kalthoff, H., Becker, T., Buchler, M.W., and Zoller, M. (2015). Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity. Int. J. Cancer 136: 2616–2627.
70 Manterola, L., Guruceaga, E., Gallego Perez-Larraya, J., Gonzalez-Huarriz, M., Jauregui, P., Tejada, S., Diez-Valle, R., Segura, V., Sampron, N., Barrena, C., Ruiz, I., Agirre, A., Ayuso, A., Rodriguez, J., Gonzalez, A., Xipell, E., Matheu, A., Lopez De Munain, A., Tunon, T., Zazpe, I., Garcia-Foncillas, J., Paris, S., Delattre, J.Y., and Alonso, M.M. (2014). A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. Neuro Oncol 16: 520–527.
71 Mathivanan, S., Ji, H., and Simpson, R.J. (2010). Exosomes: Extracellular organelles important in intercellular communication. J. Proteomics 73: 1907–1920.
72 Melo, S.A., Luecke, L.B., Kahlert, C., Fernandez, A.F., Gammon, S.T., Kaye, J., Lebleu, V.S., Mittendorf, E.A., Weitz, J., Rahbari, N., Reissfelder, C., Pilarsky, C., Fraga, M.F., Piwnica-Worms, D., and Kalluri, R. (2015). Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523: 177–182.
73 Mittelbrunn, M., Gutierrez-Vazquez, C., Villarroya-Beltri, C., Gonzalez, S., Sanchez-Cabo, F., Gonzalez, M.A., Bernad, A., and Sanchez-Madrid, F. (2011). Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat. Commun. 2: 282.
74 Mizutani, K., Terazawa, R., Kameyama, K., Kato, T., Horie, K., Tsuchiya, T., Seike, K., Ehara, H., Fujita, Y., Kawakami, K., Ito, M., and Deguchi, T. (2014). Isolation of prostate cancer-related exosomes. Anticancer Res. 34: 3419–3423.
75 Mobarrez, F., Antoniewicz, L., Bosson, J.A., Kuhl, J., Pisetsky, D.S., and Lundback, M. (2014). The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers. PLoS One 9: e90314.
76 Montecalvo, A., Larregina, A.T., Shufesky, W.J., Stolz, D.B., Sullivan, M.L., Karlsson, J.M., Baty, C.J., Gibson, G.A., Erdos, G., Wang, Z., Milosevic, J., Tkacheva, O.A., Divito, S.J., Jordan, R., Lyons-Weiler, J., Watkins, S.C., and Morelli, A.E. (2012). Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 119: 756–766.
77 Mor, E., He, L., Torchinsky, A., and Shomron, N. (2014). MicroRNA-34a is dispensable for p53 function as teratogenesis inducer. Arch. Toxicol. 88: 1749–1763.
78 Munro, T.P., Magee, R.J., Kidd, G.J., Carson, J.H., Barbarese, E., Smith, L.M., and Smith, R. (1999). Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking. J. Biol. Chem. 274: 34389–34395.
79 Naruse, M., Ono, R., Irie, M., Nakamura, K., Furuse, T., Hino, T., Oda, K., Kashimura, M., Yamada, I., Wakana, S., Yokoyama, M., Ishino, F., and Kaneko-Ishino, T. (2014). Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition. Development 141: 4763–4771.
80 Nawaz, M., Shah, N., Zanetti, B.R., Maugeri, M., Silvestre, R.N., Fatima, F., Neder, L., and Valadi, H. (2018). Extracellular vesicles and matrix remodeling enzymes: the emerging roles in extracellular matrix remodeling, progression of diseases and tissue repair. Cells 7 (10): 167.
81 Negrier, S., Gravis, G., Perol, D., Chevreau, C., Delva, R., Bay, J.O., Blanc, E., Ferlay, C., Geoffrois, L., Rolland, F., Legouffe, E., Sevin, E., Laguerre, B., and Escudier, B. (2011). Temsirolimus and bevacizumab, or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): A randomised phase 2 trial. Lancet. Oncol. 12: 673–680.
82 Ogata-Kawata, H., Izumiya, M., Kurioka, D., Honma, Y., Yamada, Y., Furuta, K., Gunji, T., Ohta, H., Okamoto, H., Sonoda, H., Watanabe, M., Nakagama, H., Yokota, J., Kohno, T., and Tsuchiya, N. (2014). Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS One 9: e92921.
83 Okada, C., Yamashita, E., Lee, S.J., Shibata, S., Katahira, J., Nakagawa, A., Yoneda, Y., and Tsukihara, T. (2009). A high-resolution structure of the pre-microRNA nuclear export machinery. Science 326: 1275–1279.
84 Ono, R., Ishii, M., Fujihara, Y., Kitazawa, M., Usami, T., Kaneko-Ishino, T., Kanno, J., Ikawa, M., and Ishino, F. (2015). Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes. Sci. Rep. 5: 12281.
85 Ono, R., Kobayashi, S., Wagatsuma, H., Aisaka, K., Kohda, T., Kaneko-Ishino, T., and Ishino, F. (2001). A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21. Genomics 73: 232–237.
86 Ono, R., Kuroki, Y., Naruse, M., Ishii, M., Iwasaki, S., Toyoda, A., Fujiyama, A., Shaw, G., Renfree, M.B., Kaneko-Ishino, T., and Ishino, F. (2011). Identification of tammar wallaby SIRH12, derived from a marsupial-specific retrotransposition event. DNA Res. 18: 211–219.
87 Ono, R., Nakamura, K., Inoue, K., Naruse, M., Usami, T., Wakisaka-Saito, N., Hino, T., Suzuki-Migishima, R., Ogonuki, N., Miki, H., Kohda, T., Ogura, A., Yokoyama, M., Kaneko-Ishino, T., and Ishino, F. (2006). Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Nat. Genet. 38: 101–106.
88 Ono, R., Shiura, H., Aburatani, H., Kohda, T., Kaneko-Ishino, T., and Ishino, F. (2003). Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Genome Res. 13: 1696–1705.
89 Ono, R., Yasuhiko, Y., Aisaki, K.I., Kitajima, S., Kanno, J., and Hirabayashi, Y. (2019). Exosome-mediated horizontal gene transfer occurs in double-strand break repair during genome editing. Commun. Biol. 2: 57.
90 Ono, R., Yoshioka, Y., Furukawa, Y., Naruse, M., Kuwagata, M., Ochiya, T., Kitajima, S., and Hirabayashi, Y. (2020). Novel hepatotoxicity biomarkers of extracellular vesicle (EV)-associated miRNAs induced by CCl4. Toxicol. Rep. 7: 685–692.
91 Ostertag, E.M., Prak, E.T., Deberardinis, R.J., Moran, J.V., and Kazazian, H.H.J.R. (2000). Determination of L1 retrotransposition kinetics in cultured cells. Nucleic Acids Res. 28: 1418–1423.
92 Paggetti, J., Haderk, F., Seiffert, M., Janji, B., Distler, U., Ammerlaan, W., Kim, Y.J., Adam, J., Lichter, P., Solary, E., Berchem, G., and Moussay, E. (2015). Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts. Blood 126: 1106–1117.
93 Pan, B.T. and Johnstone, R.M. (1983). Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor. Cell 33: 967–978.
94 Pan, B.T., Teng, K., Wu, C., Adam, M., and Johnstone, R.M. (1985). Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 101: 942–948.
95 Pegtel, D.M., Cosmopoulos, K., Thorley-Lawson, D.A., Van Eijndhoven, M.A., Hopmans, E.S., Lindenberg, J.L., De Gruijl, T.D., Wurdinger, T., and Middeldorp, J.M. (2010). Functional delivery of viral miRNAs via exosomes. Proc. Natl. Acad. Sci. USA 107: 6328–6333.
96 Peinado, H., Aleckovic, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., Garcia-Santos, G., Ghajar, C., Nitadori-Hoshino,