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18 Chapter 10: Medications used in the cardiovascular system Aim Introduction Medications used in the management of cardiovascular diseases Atheroma and the hyperlipidaemias Medications used to regulate lipids: Antihyperlipidaemic medications Statins: HMG‐CoA reductase inhibitors Inhibitors of cholesterol absorption Fibrates Bile‐acid‐binding resins: Cholesterol absorption inhibitors PCSK9 inhibitors Alternatives to statins Medications used in management of hypertension Medications used to manage hypertension Angiotensin‐converting enzyme inhibitors (ACEi) Calcium channel blockers (CCBs) Diuretics Loop diuretics Thiazide diuretics Potassium‐sparing diuretics Angiotensin receptor blockers (ARBs) Beta‐adrenoceptor antagonists (beta‐blockers) Alpha‐adrenergic blockers: Alpha blockers Vasodilators Central acting agents Direct renin inhibitors (DRIs) Medications used in managing ischaemic heart disease Isosorbide dinitrate and isosorbide mononitrate Potassium channel activators Medications used for cardiac arrhythmias Disorders of heart rhythm and rate Amiodarone Digoxin Magnesium sulphate Arrhythmias due to conduction defects Atropine sulphate Medications used in the management of heart failure Medications used in heart failure Mineralocorticoid receptors antagonist (MRAs) Reducing the workload of the heart Hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channel blockers Angiotensin receptor neprilysin inhibitors Optimising contractility of the heart Medications that affect haemostasis Antiplatelet medications Clopidogrel, Prasugrel and Ticagrelor Dipyridamole Glycoprotein 11b/111a inhibitors Anticoagulants Heparin Low molecular weight fragments of heparin (LMWH) Vitamin K inhibitors Direct‐acting oral anticoagulants (DOACs) The thrombolytics Medications used in peripheral vascular disease Pharmacological interventions: The future Conclusion References Further reading Multiple choice questions
19 Chapter 11: Medications and the renal system Aim Introduction Anatomy and physiology of the renal tract Common renal conditions Drug‐induced renal damage Drug classes that act upon the renal system Drugs used to treat fluid retention Drugs used to treat electrolyte disorders Drugs used to treat urinary retention and urinary incontinence