plague epidemic was the one in the midfourteenth century that raged across all of Europe, Asia and North Africa. Known as the Black Death or the Pestilence, it killed 25 million people, or half the population of the affected continents. The epidemic began in Asia and spread throughout Europe in just three years. The practice of quarantine (isolating a person who’s suspected of being infected) dates precisely from this period. There were several outbreaks of Black Death in Europe until it was seen for the last time in the seventeenth century in the north of the continent, and in the eighteenth century in the south.
The bacterium responsible for plague wasn’t discovered until the nineteenth-century epidemic that hit China. In 1894, Alexandre Yersin and Shibasaburo Kitasato independently identified it in Hong Kong. The Swiss Yersin was having problems in studying the disease as he wasn’t permitted to examine the bodies of the victims, which were all being sent to Kitasato’s laboratory. At the time, the latter, an eminent microbiologist, especially well known for his work with Robert Koch on tuberculosis and tetanus, was the clear preference of the authorities. By contrast, Yersin received no support, but he wasn’t discouraged by that. He built a thatched hut, which became his laboratory, and started bribing morgue workers to give him access to the victims. Despite all the difficulties, Yersin ended up with the fame, partly because of errors in Kitasato’s work. Yersin decided to name the new microbe Pasteurella pestis in honour of Pasteur but, years after his death, the name was changed to Yersinia in recognition of his contribution.
As I’ve said, plague is far from being a thing of the past. For example, there was an outbreak in China in early August 2009. It was a pneumonic plague and, by the time it was made public, ten people were infected and two had died. The authorities immediately quarantined 10,000 people to stop the contagion from spreading.
The ‘Spanish’ flu
The first known influenza pandemic is that of 1580 and, since then, there have been about thirty major outbreaks. In the twentieth century, for example, there were four: in 1900, 1918, 1957 and 1968. The pandemic of 1918 deserves special mention, as the last major health catastrophe of the twentieth century to affect the whole world – at least until the onset of AIDS. In terms of the number of victims, it’s considered to rank third among the pandemics (after the Black Death of the Middle Ages and the smallpox that exterminated most of America’s indigenous peoples).
Although the 1918 pandemic is traditionally called ‘Spanish flu’, the part of the globe where it began isn’t known for sure. Spain was the first country to report cases – hence the name. In the debate about its origins, the main suspects are France, the United States, Spain itself and some countries of Asia. The final death toll isn’t clear either. The figures range from 20 to 100 million people, according to different studies or, in other words, up to ten times more than the number of people who died in the First World War. This could signify between 2 per cent and 5 per cent of the total population of the planet (of which possibly 50 per cent was infected), with particularly high rates among people aged between 25 and 45.
Oddly enough, rather than being directly caused by the influenza virus itself, most deaths were the result of pneumonia brought on by bacteria. The virus would have broken through the physical barriers protecting the airways, thereby allowing the bacteria, which are normally on the surface and don’t cause problems, to get inside tissues and end up causing deadly infections. It’s thought that this is partly why the death tolls of the 1957 and 1968 pandemics were much lower (100,000 and 700,000 respectively), because antibiotics to fight secondary bacterial infections were then available to everyone, while they didn’t exist in 1918. The treatments recommended then didn’t go beyond leeches (to suck blood, which was thought to balance the body ‘humours’) or rubbing with menthol, both of which were clearly useless.
Sometimes pandemics have sneaky beginnings. In this case, for example, the first flu outbreak in January 1918 was mild and nobody regarded it as being more serious than a normal flu. By spring that year, it was already crossing the United States, but still no one paid much attention. Meanwhile, in Europe, fully embroiled in the First World War, it was starting to be a more serious problem. That summer, a second outbreak, more serious than the first one, began in Switzerland and reached American shores in September that year. Most cases were clustered in October and November, but a third wave was to appear early in 1919, followed by a fourth and final minor one in the spring of 1920.
The pandemic worsened because of mismanagement by the authorities, a state of affairs that has kept recurring throughout history, to this very day. For example, the US government’s tactic was to downplay it. President Woodrow Wilson didn’t make a single declaration about the situation. The authorities asserted that there was no reason to be alarmed if proper precautions were taken. The government said it didn’t want the population to feel demoralized because ‘fear kills more people than the disease’, as a public health commissioner in Chicago put it. The aim was to make Americans believe that the pandemic was nothing worse than seasonal flu. Yet the symptoms were very different. Some infected people died within twenty-four hours, bleeding from their eyes and ears. The number of victims was rising by the day, but the authorities kept insisting that the outbreak was ending. The effect was exactly the opposite of what they hoped for: people in the United States lived in a state of fear, unable to trust the media and attentive only to rumours. They stopped going to work, shops closed, and the transport, food distribution, shops, medical treatment and communication systems all broke down. Only a few cities, San Francisco among them, decided to break the code of silence and alert the population in order to avoid total collapse.
We don’t learn from our errors
The organizational problems that aggravate the effects of a pandemic today are less common, but they still exist. The dithering of many leaders in 2020 when faced with the beginnings of the COVID-19 pandemic would be an example of this. Nevertheless, it’s been worse on other occasions. With the onset of the 2003 SARS epidemic, the Chinese government concealed the outbreak, thus causing panic in the cities because of lack of information and feelings of mistrust. The same thing happened in the early days of the bird flu outbreak when the governments of Thailand and Indonesia concealed information. And during the 2009 swine flu outbreak, even though the data flowed fast and clearly in most parts of the world, in countries like Argentina, the attempts of politicians to cover up the gravity of the situation contributed towards increased levels of contagion.
The response in Spain was not unlike that in the United States. Although it was the first country to recognize publicly that it had been hit by an epidemic, this didn’t happen until five months after its onset. By then it was too late to stop it. The only solution was to hide. People protected themselves by covering their faces with handkerchiefs and locking themselves away in their houses. The dead were unceremoniously buried in mass graves for fear of contagion, a task the army frequently had to deal with as the citizens were unwilling to do it. In the villages, churches were forbidden to toll the death knell in order not to further demoralize the population, and life was all but paralysed for several months. The government had little idea of what measures to take, as was demonstrated by the fact that the beginning of the school year was delayed in order to prevent gatherings in classrooms, but crowd-pulling shows weren’t banned. In Barcelona, even when the governor finally decided to cancel the main public events scheduled for that autumn, the Swiss founder of Barça, Joan Gamper, demonstrating that the threat wasn’t taken seriously enough, decided to ignore this precautionary measure and to go ahead with the first match of the Catalonia championship, with the excuse that it would be in the open air with minimal risk of contagion.
The resuscitated virus
In 2005, a group of scientists, including Adolfo García-Sastre, a Spanish virologist working at the Mount Sinai Hospital, New York, managed to read the genome sequence of the virus that caused the 1918 flu pandemic. The biological material was taken from a well-conserved frozen corpse found in the glaciers of Alaska. The genetic information they obtained allowed them to re-create the virus in the laboratory and, with this synthetic virus, to reproduce the lethal effects of the infection in mice. The