244
249 245
250 246
251 247
252 248
253 249
254 250
255 251
256 252
257 253
258 254
259 255
260 256
261 257
262 258
263 259
264 260
265 261
266 262
267 263
268 264
269 265
270 266
271 267
272 268
273 269
274 270
275 271
276 272
277 273
278 274
279 275
280 276
281 277
Chemistry and Biology of Non-Canonical Nucleic Acids
Naoki Sugimoto
Author
Prof. Naoki Sugimoto Konan University Frontier Institute for Biomolecular Engineering 7-1-20 Minatojima-minamimachi 650-0047 Kobe Japan
All books published by Wiley-VCH are carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details, or other items may inadvertently be inaccurate.
Library of Congress Card No.: applied for
British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library.
Bibliographic information published by the Deutsche Nationalbibliothek The Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at <http://dnb.d-nb.de>.
© 2021 WILEY-VCH GmbH, Boschstr. 12, 69469 Weinheim, Germany
All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law.
Print ISBN: 978-3-527-34521-2 ePDF ISBN: 978-3-527-81788-7 ePub ISBN: 978-3-527-81786-3 oBook ISBN: 978-3-527-81785-6
Preface
In chemistry and biology, one of the most important and interesting research subjects is nucleic acids: DNA and RNA. The nucleic acids consist of very simple materials: phosphate, sugar, and organic bases. Their structures are also very simple as single strands or a double helix, in comparison with another biomolecules such as proteins and carbohydrates; however the nucleic acids have very important genetic information and functions.
As I mentioned in the Introduction in Chapter 1, there is close to 70 years history in nucleic acid research after the discovery of the double helix DNA structure (B-form) as the canonical one by James Dewey Watson and Francis Harry Compton Crick in 1953 and chemical biology of nucleic acids are facing to new aspect today, that is, non-canonical nucleic acids. Through this book, I expect that readers understand how uncommon structure of nucleic acids became one of the common structures as non-canonical nucleic acids that fascinate us now. This new research field for non-canonical nucleic acids will soon big-spark at the interface of chemistry and biology.
This book is comprised of 15 chapters covering various aspects of chemistry and biology of non-canonical nucleic acids including not only their history, structures, stabilities, and properties but also their functions on transcription, translation, regulation, telomere, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and future outlook. This book is a valuable resource, not only for graduate students but also researchers in the fields of physical chemistry, organic chemistry, inorganic chemistry, analytical chemistry, biochemistry, biophysics, structural biology, computational biology, molecular medicine, molecular biology, cell biology, and nanotechnology and who would like to learn more about the potential important roles of non-canonical nucleic acids as well as canonical ones.
I wish all readers enjoy this book and know the importance of not only Watson–Crick double helical nucleic acids (B-form) but also non-canonical nucleic acids like triplex and quadruplex. Instead of Hamlet by written by William Shakespeare, please answer the question “To B or not to B, that is the question” in the research field of nucleic acids.
I am deeply grateful to my colleagues in FIBER (Frontier Institute for Biomolecular Engineering Research), Konan University, for their excellent contribution to my writing as the co-authors at the following each chapter. They are Dr. Shuntaro Takahashi (for Chapters 1, 4, 5, 8, 9, 14, and 15), Dr. Tamaki Endoh (for Chapters 2, 7, 10, 13, and 15), and Dr. Hisae Tateishi-Karimata (for Chapters 3, 6, 11, 12,