document elaborated by Special Interest Groups (SIG) “cachexia‐anorexia in chronic wasting diseases” and “nutrition in geriatrics”. Clin Nutr 2010; 29(2):154–9.
2 2. Anker SD, Morley JE, von Haehling S. Welcome to the ICD‐10 code for sarcopenia. J Cachexia Sarcopenia Muscle 2016; 7(5):512–4.
3 3. Ethgen O, Beaudart C, Buckinx F, Bruyere O, Reginster JY. The future prevalence of sarcopenia in Europe: a claim for public health action. Calcif Tissue Int 2017; 100(3):229–34.
4 4. Nilwik R, Snijders T, Leenders M, Groen BB, van Kranenburg J, Verdijk LB, van Loon LJ. The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fibre size. Exp Gerontol 2013; 48(5):492–8.
5 5. Katsanos CS, Kobayashi H, Sheffield‐Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 2006; 291(2):E381–7.
6 6. Paddon‐Jones D, Sheffield‐Moore M, Zhang XJ, Volpi E, Wolf SE, Aarsland A, Ferrando AA, Wolfe RR. Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab 2004; 286(3):E321–8.
7 7. Dardevet D, Remond D, Peyron MA, Papet I, Savary‐Auzeloux I, Mosoni L. Muscle wasting and resistance of muscle anabolism: the “anabolic threshold concept” for adapted nutritional strategies during sarcopenia. ScientificWorldJournal 2012; 2012:269531.
8 8. Guillet C, Prod'homme M, Balage M, Gachon P, Giraudet C, Morin L, Grizard J, Boirie Y. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J 2004; 18(13):1586–7.
9 9. Wall BT, Gorissen SH, Pennings B, Koopman R, Groen BB, Verdijk LB, van Loon LJ. Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion. PLoS One 2015; 10(11):e0140903.
10 10. Cruz‐Jentoft AJ, Sayer AA. Sarcopenia. Lancet 2019; 393(10191):2636–46.
11 11. Baar K. Epigenetic control of skeletal muscle fibre type. Acta Physiol (Oxf) 2010; 199(4):477–87.
12 12. Beaudart C, Dawson A, Shaw SC, Harvey NC, Kanis JA, Binkley N, Reginster JY, Chapurlat R, Chan DC, Bruyere O, et al. Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review. Osteoporos Int 2017; 28(6):1817–33.
13 13. Short KR, Nair KS. The effect of age on protein metabolism. Curr Opin Clin Nutr Metab Care 2000; 3(1):39–44.
14 14. Walrand S, Boirie Y. Optimizing protein intake in aging. Curr Opin Clin Nutr Metab Care 2005; 8(1):89–94.
15 15. Wall BT, van Loon LJ. Nutritional strategies to attenuate muscle disuse atrophy. Nutr Rev 2013; 71(4):195–208.
16 16. Volpi E, Ferrando AA, Yeckel CW, Tipton KD, Wolfe RR. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest 1998; 101(9):2000–7.
17 17. Volpi E, Mittendorfer B, Wolf SE, Wolfe RR. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first‐pass splanchnic extraction. Am J Physiol 1999; 277(3 Pt 1):E513–20.
18 18. Boirie Y, Gachon P, Beaufrere B. Splanchnic and whole‐body leucine kinetics in young and elderly men. Am J Clin Nutr 1997; 65(2):489–95.
19 19. Volpi E, Kobayashi H, Sheffield‐Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 2003; 78(2):250–8.
20 20. Katsanos CS, Kobayashi H, Sheffield‐Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 2005; 82(5):1065–73.
21 21. Dardevet D, Sornet C, Bayle G, Prugnaud J, Pouyet C, Grizard J. Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine‐supplemented meal. J Nutr 2002; 132(1):95–100.
22 22. Mosoni L, Valluy MC, Serrurier B, Prugnaud J, Obled C, Guezennec CY, Mirand PP. Altered response of protein synthesis to nutritional state and endurance training in old rats. Am J Physiol 1995; 268(2 Pt 1):E328–35.
23 23. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose‐induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 2000; 85(12):4481–90.
24 24. Arnal MA, Mosoni L, Boirie Y, Houlier ML, Morin L, Verdier E, Ritz P, Antoine JM, Prugnaud J, Beaufrere B, et al. Protein pulse feeding improves protein retention in elderly women. Am J Clin Nutr 1999; 69(6):1202–8.
25 25. Boirie Y, Gachon P, Cordat N, Ritz P, Beaufrere B. Differential insulin sensitivities of glucose, amino acid, and albumin metabolism in elderly men and women. J Clin Endocrinol Metab 2001; 86(2):638–44.
26 26. Guillet C, Zangarelli A, Gachon P, Morio B, Giraudet C, Rousset P, Boirie Y. Whole body protein breakdown is less inhibited by insulin, but still responsive to amino acid, in nondiabetic elderly subjects. J Clin Endocrinol Metab 2004; 89(12):6017–24.
27 27. Rasmussen BB, Fujita S, Wolfe RR, Mittendorfer B, Roy M, Rowe VL, Volpi E. Insulin resistance of muscle protein metabolism in aging. FASEB J 2006; 20(6):768–9.
28 28. Boirie Y, Short KR, Ahlman B, Charlton M, Nair KS. Tissue‐specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin. Diabetes 2001; 50(12):2652–8.
29 29. Fujita S, Rasmussen BB, Cadenas JG, Grady JJ, Volpi E. Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin‐induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab 2006; 291(4):E745–54.
30 30. Biolo G, Declan Fleming RY, Wolfe RR. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J Clin Invest 1995; 95(2):811–9.
31 31. Timmerman KL, Lee JL, Fujita S, Dhanani S, Dreyer HC, Fry CS, Drummond MJ, Sheffield‐Moore M, Rasmussen BB, Volpi E. Pharmacological vasodilation improves insulin‐stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes 2010; 59(11):2764–71.
32 32. Rieu I, Magne H, Savary‐Auzeloux I, Averous J, Bos C, Peyron MA, Combaret L, Dardevet D. Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats. J Physiol 2009; 587(Pt 22):5483–92.
33 33. Tardif N, Salles J, Landrier JF, Mothe‐Satney I, Guillet C, Boue‐Vaysse C, Combaret L, Giraudet C, Patrac V, Bertrand‐Michel J, et al. Oleate‐enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats. Clin Nutr 2011; 30(6):799–806.
34 34. Annweiler C, Henni S, Walrand S, Montero‐Odasso M, Duque G, Duval GT. Vitamin D and walking speed in older adults: systematic review and meta‐analysis. Maturitas 2017; 106:8–25.
35 35. Duval G, Rolland Y, Schott AM, Blain H, Dargent‐Molina P, Walrand S, Duque G, Annweiler C. Association of hypovitaminosis D with triceps brachii muscle fatigability among older women: findings from the EPIDOS cohort. Maturitas 2018; 111:47–52.
36 36. Chanet A, Salles J, Guillet C, Giraudet C, Berry A, Patrac V, Domingues‐Faria C, Tagliaferri C, Bouton K, Bertrand‐Michel J, et al. Vitamin D supplementation restores the blunted muscle protein synthesis response in deficient old rats through an impact on ectopic fat deposition. J Nutr Biochem 2017; 46:30–8.
37 37. El Hajj C, Fares S, Chardigny JM, Boirie Y, Walrand S. Vitamin D supplementation and muscle strength in pre‐sarcopenic elderly Lebanese people: a randomized controlled trial. Arch Osteoporos 2018; 14(1):4.
38 38. Salles J, Chanet A, Giraudet C, Patrac V, Pierre P, Jourdan M, Luiking YC, Verlaan S, Migne C, Boirie Y, et al. 1,25(OH)2‐vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes. Mol Nutr Food Res 2013; 57(12):2137–46.
39 39. Clugston G, Dewey KG, Fjeld