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Bioethics


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obtained. In addition, when prospective parents are both heterozygous for a dominant genetic disorder, the risk of transmission is as high as 75%, hence the chances of finding mutation‐free embryos significantly low. Another case where PGD is not effective is when both parents are homozygous for a recessive genetic disorder, meaning that they both carry two variants of the disease‐causing gene (Nuffield Council on Bioethics 2016; Vassena et al. 2016). In such cases, genome editing could represent an alternative to PGD and a new reproductive option for some prospective parents: mutations potentially leading to monogenic diseases would be corrected in embryos created with IVF prior to the transfer in utero or directly onto prospective parents’ gametes prior to fertilisation. Lastly, gene editing could replace PGD for women at risk of transmitting mitochondrial diseases as mitochondrial DNA mutations present in oocytes2 could be corrected in the embryo (Vassena et al. 2016).

      Gene‐editing technologies have been around for over a decade. Zinc finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs), two gene‐editing technologies, were discovered in 2005 and 2010 respectively (Nuffield Council on Bioethics 2016). ZFNs and TALENs are relatively precise techniques, but have the disadvantage that they need engineered proteins to target specific sequences of the DNA, a procedure that requires time and resources (Nuffield Council on Bioethics 2016).

      A new gene editing technique sparked debate early in 2015 due to its application on non‐viable human embryos by a group of Chinese scientists (Baltimore et al. 2015; Lanphier and Urnov 2015). The technique in question is CRISPR/Cas9, an RNA‐guided tool composed of two parts: clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR‐associated protein 9 (Cas9). CRISPR/Cas9 makes use of a naturally occurring defence mechanism that bacteria use to avoid harmful infections caused by pathogenic organisms (e.g. viruses). The RNA tool (CRISPR) functions as a guide for the Cas proteins to target specific parts of the genome, which are subsequently cut by the Cas proteins. These cut strands can be exploited to modify the nucleotide sequence of DNA and to insert genes at the cut site. The application of this technique to human embryos and human gametes (i.e. oocytes and sperm cells) has been widely criticised for a number of issues, but chiefly for its potential to introduce inheritable changes in the human genome (germline modification). Indeed, the issue of germline modification has catalysed the attention of many scientists and ethicists (Brokowski et al. 2015; Lander 2015; Lanphier and Urnov 2015).

      The other argument against allowing genome editing for clinical uses is concern for the safety of future offspring (and of this offspring’s offspring). At this stage, safety is indeed an issue and the efficiency of genome editing on embryos remains low, with mosaic embryos (i.e. embryos that have abnormal numbers of chromosomes in certain cells resulting in genetically different cells coexisting in the same organism) being the main known drawback of these technologies (Vassena et al. 2016). Despite this, some studies have proven the feasibility of gene editing in animals (Heo et al. 2014;