20.7 Effects of Biofilm on Host Tissues and Biomaterial Interactions 20.8 Strategies for Controlling Implant Infections 20.9 Concluding Remarks Problems References Further Reading 21 Response to Surface Topography and Particulate Materials 21.1 Introduction 21.2 of Biomaterial Surface Topography on Cell Response 21.3 Biomaterial Surface Topography for Antimicrobial Activity 21.4 Microparticle‐Induced Host Responses 21.5 Nanoparticle‐Induced Host Responses 21.6 Concluding Remarks Problems References Further Readings 22 Tests of Biocompatibility of Prospective Implant Materials 22.1 Introduction 22.2 Biocompatibility Standards and Regulations 22.3 In vitro Biocompatibility Test Procedures 22.4 In vivo Biocompatibility Test Procedures 22.5 Clinical Trials of Biomaterials 22.6 FDA Review and Approval 22.7 Case Study: The Proplast Temporomandibular Joint 22.8 Concluding Remarks Problems References Further Reading
11 Part VI: Applications of Biomaterials 23 Biomaterials for Hard Tissue Repair 23.1 Introduction 23.2 Healing of Bone Fracture 23.3 Healing of Bone Defects 23.4 Total Joint Replacement 23.5 Spinal Fusion 23.6 Dental Implants and Restorations 23.7 Concluding Remarks Problems References Further Reading 24 Biomaterials for Soft Tissue Repair 24.1 Introduction 24.2 Surgical Sutures and Adhesives 24.3 The Cardiovascular System 24.4 Vascular Grafts 24.5 Balloon Angioplasty 24.6 Intravascular Stents 24.7 Prosthetic Heart Valves 24.8 Ophthalmologic Applications 24.9 Skin Wound Healing 24.10 Concluding Remarks Problems References Further Reading 25 Biomaterials for Tissue Engineering and Regenerative Medicine 25.1 Introduction 25.2 Principles of Tissue Engineering and Regenerative Medicine 25.3 Biomaterials and Scaffolds for Tissue Engineering 25.4 Creation of Scaffolds for Tissue Engineering 25.5 Three‐dimensional Bioprinting 25.6 Tissue Engineering Techniques for the Regeneration of Functional Tissues and Organs 25.7 Concluding Remarks Problems References Further Reading 26 Biomaterials for Drug Delivery 26.1 Introduction 26.2 Controlled Drug Release 26.3 Designing Biomaterials for Drug Delivery Systems 26.4 Microparticle‐based Delivery Systems 26.5 Hydrogel‐based Delivery Systems 26.6 Nanoparticle‐based Delivery Systems 26.7 Delivery of Ribonucleic Acid (RNA) 26.8 Biological Drug Delivery Systems 26.9 Concluding Remarks Problems References Further Reading
12 Index