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CELL BIOLOGY
A Short Course
FOURTH EDITION
Stephen Bolsover
Andrea Townsend‐Nicholson
Greg FitzHarris
Elizabeth Shephard
Jeremy Hyams
Sandip Patel
This fourth edition first published 2022
© 2022 John Wiley & Sons Ltd
Edition History John Wiley & Sons, Inc. (From Genes to Cells, 1e, 1997) (2e, 2004) (3e, 2011)
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Library of Congress Cataloging‐in‐Publication Data applied for
Names: Bolsover, Stephen, 1954‐ author.
Title: Cell biology: a short course / Stephen Bolsover, Andrea Townsend‐Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, Sandip Patel.
Description: Fourth edition. | Hoboken, NJ: Wiley‐Blackwell, 2022. | Includes bibliographical references and index.
Identifiers: LCCN 2021049318 (print) | LCCN 2021049319 (ebook) | ISBN 9781119757764 (hardback) | ISBN 9781119757771 (adobe pdf) | ISBN 9781119757788 (epub)
Subjects: LCSH: Cytology.
Classification: LCC QH581.2 .B65 2022 (print) | LCC QH581.2 (ebook) | DDC 571.6–dc23/eng/20211007
LC record available at https://lccn.loc.gov/2021049318 LC ebook record available at https://lccn.loc.gov/2021049319
Cover Design: Wiley
Cover Image: © Hybrid Medical Animation/Science Source
PREFACE
Our aim in previous editions of Cell Biology, A Short Course was to cover a wide area of cell biology in a form especially suitable for first‐year undergraduates, keeping the book to a manageable size so that neither the content, the cost, nor the weight was too daunting for the student. For the fourth edition we have thoroughly revised the content to concentrate on the core of cell biology: the structure of the cell, how it is made, and how cells and the parts of cells interact and move.
We begin (Section 1, Chapters 1 and 2) by describing the components of the cell as seen in the microscope. We then (Section 2, Chapters 3–8) turn to the central dogma of molecular biology and describe how DNA is used to make RNA which in turn is used to make protein. We end this section with chapters on protein structure and on recombinant DNA technology and genetic engineering. Section 3 (Chapters 9–11) describes how cells use electricity, ion concentrations, and chemical messengers to interact with and respond to external cues. Section 4 (Chapters 12–14) describes the physically moving cell: intracellular trafficking, the cytoskeleton and molecular motors, and cell division and death. Finally, in Section 5 (Chapter 15) we use cystic fibrosis as a case study that illustrates how all the areas of knowledge covered in this book contribute to an understanding of this disease and have allowed the development of novel clinical treatments.
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