1641 1636
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1648 1643
1649 bi
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1652 biv
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1657 bix
1658 bx
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1663 bxv
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1687 xl
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1697 l
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1722 1644
To my wife, Caroline, and children and grandchildren, present and future, for their invaluable contributions to my work, my life, and my happiness!
Alan J. Sinclair
To all my older friends and patients who have taught me geriatrics; to my wife, Pat, and my children, Robert, Susan, and Jacqueline; and to my grandchildren, Amanda, Conor, Katelyn, Nicole, Paige, and John, who are my eternal joy and my hope for the future of eldercare.
John E. Morley
Geriatric medicine is moving to healthy ageing and prevention. Of course, we will still have to take care of frail and sick older people, but this move will change geriatric medicine in everyday clinical practice more each year. I dedicate this textbook to my family and all those scientists that have inspired us to bring about positive change in the way we manage older people, such as Professor Alan Sinclair and those who continue to excel, as otherwise this textbook would not have been possible.
Bruno Vellas
To my family.
Matteo Cesari
To my patients, who taught me the most important lessons on how to age gracefully.
Medha Munshi
Pathy’s Principles and Practice of Geriatric Medicine
SIXTH EDITION
Volume 1
Edited by
Alan J. Sinclair
Director, Foundation for Diabetes Research in Older People (fDROP);
King’s College, London, UK
John E. Morley
Emeritus Professor of Internal Medicine
Division of Geriatric Medicine
Saint Louis University School of Medicine
St Louis, Missouri, USA
Bruno Vellas
Chair, Gérontopôle & Department of Geriatric Internal Medicine
Toulouse University Hospital
Toulouse, France
Matteo Cesari
Associate Professor of Geriatrics
Università di Milano;
Head, Geriatric Unit
IRCCS Istituti Clinici Scientifici Maugeri
Milano, Italy
Medha Munshi
Associate Professor of Medicine
Harvard Medical School;
Geriatrician and Endocrinologist
Beth Israel Deaconess Medical Center
Boston, Massachusetts, USA
This edition first published 2022
© 2022 John Wiley & Sons Ltd
Edition History John Wiley & Sons, Ltd (5e, 2012)
All rights reserved. No part of this publication may be reproduced, stored in