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Human Milk: Composition, Clinical Benefits and Future Opportunities


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and Children

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      Conclusions

      Studies on the supplementation of bovine MFGM to the diet of infants and children have shown promising results regarding both neurodevelopment and defense against infections. These findings are supported by known effects of individual components of MFGM mostly based on in vitro and/or animal studies. However, the scientific base of knowledge for MFGM supplementation to infants and children is still limited. The number of published studies on MFGM supplementation to infants and children is small, and the interventions are heterogeneous: different MFGM concentrates have been given for different durations at different ages and with different main outcomes. However, MFGM supplementation seems safe down to the age of the first week of life in term infants, as no serious adverse effects have been reported.

      Infant formulas supplemented with bovine MFGM concentrates have already been launched on many markets, but before any general recommendations or guidelines of MFGM use in infants and children can be given, more high-quality DBRCTs are needed.

      Disclosure Statement

      O.H. has participated as a clinical investigator and/or scientific advisory board member, speaker, and consultant for Semper, Hero, Mead Johnson Nutrition, Arla Foods, Arla Foods Ingredients, Nestlé Nutrition Institute, and Hipp. M.D. has participated as clinical investigator and/or speaker for Hero, Semper,