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Phytopharmaceuticals


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Rosehip oil FT-MIR PLS-DA [185] Discrimination of different parts of a plants Commifora wightii GC–MS NMR PCA PLS-DA [189]

      The characterization of natural ingredients including biocompounds eco-friendly extracted from undervaluated non-traditional sources will be an attractive topic in medicinal, food and even in cosmetic industries.

      Many nontraditional unexploited sources of bioactive compounds, such as native botanicals, by products and wastes from agroindustrial production have been presented. However, some aspects should be overcome before they could be effectively employed for nutraceutical, pharmaceutical or cosmetic applications, which comprise:

      1 a) The implementation of adequate extraction techniques, which not only reduce time and save operational costs, but also allow to assess complete bioactive release from the vegetable matrices. Research has to be done also for the transference of these technologies from laboratory to industrial scale.

      2 b) The standardization of analytical procedures for evaluating the pursued functions, with adequate interlaboratory comparisons. At this point, it is important to clearly indicate the expression of bioactives concentrations. We suggest to do that on dry basis of the original material.

      3 c) The availability of conservation techniques for bioactives and adequate coating materials, which are important strategies to increase the possibilities of the industrial application of natural components, allowing the modification of release kinetics.

      4 d) The use of multivariate methods, which allow interpreting data represented in the multiple variables that include analytical results and samples composition and conditions.

      Other important issues for nutraceuticals or pharmaceuticals development, are the definition of effective dose or maximum daily allowance for a given bioactive and the effective absorption and distribution of the bioactives in the body, which requires the performance of digestibility tests.

      The authors acknowledge Red Temática CYTED, Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo 415RT0495 (LACFUN) and to PDTS CIN_CONICET 0196 Project.

CYTED Iberoamerican Program of Science and Technology for Development
GG guar gum
ECG Espina corona seed gum
VG vinal seed gum
PAEG Prosopis alba exudate gum
ANMAT Argentine National Administration of Drugs, Food and Medical Technology
OE Oleuropein
OLE olive leaves extracts
LPH lactase florocin hydrolase
HT hydroxytyrosol
UAE ultrasound assited extraction
EAE enzymes assisted extraction
MAE microwaves assisted extraction
DMAE Dynamic microwave assisted extraction
EUMAE Enzyme-based ultrasonic/microwave-assisted extraction
CDs cyclodextrins
DPPH diphenyl picryl hydrazyl
ABTS 2,2-azinobis 3-ethyl-benzothiazoline-6-sulfonic
TP total phenols
AA antioxidant activity
K Kardinal
GG Gran Gala
KR King’s Ransom
CC Cristóbal Colón
FRAP ferrric reducing
CUPRAC cupric reducing antioxidant capacity
ORAC oxygen radical absorbance capacity
TLC Thin layer chromatography
RR Rapistrum rugosum
SA Sinapis arvensis
HRMS high resolution mass spectroscopy
BSA bovine serum albumin
PBS phosphate buffered saline solution
AGEs advanced glycosilation end products
CEL Nε-carboxyethyllysine
Nε-carboxymethyl-lysine
HPLC hight performance liquid chromatography (DAD: is with diode array detection)
FPI Flaxseed protein
FG flaxseed gum
GE Gelatine
SA sodium alginate
GDL glucono-β-lactone
MVA Multivariate analysis
PCA principal component analysis